| Acid-labile liposome/pDNA complexes. | |
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MedLine Citation:
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PMID: 20072897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the bottlenecks to achieve gene or drug delivery to cells is the spatio-temporal release of the cargo to effect the correct task wherever and whenever it is supposed to. The aim of this chapter is to describe the synthesis and properties of lipids, which can form liposome complexes with DNA and to fall apart in slight acidic condition such as those encountered in the late endosome, thus destabilizing the liposome membrane and releasing their content. |
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Authors:
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Michel Bessodes; Daniel Scherman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 605 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-14 Completed Date: 2010-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 405-23 Citation Subset: IM |
Affiliation:
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Unit? de Pharmacologie Chimique et G?n?tique, Inserm, U640, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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chemistry DNA / administration & dosage* Genes, Reporter Hela Cells Humans Hydrogen-Ion Concentration Lipids / chemical synthesis, chemistry* Liposomes / chemistry* Molecular Structure Plasmids / administration & dosage Transfection* |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Lipids; 0/Liposomes; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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