Document Detail


Acid-Base Parameters for Predicting Magnetic Resonance Imaging Measures of Neurologic Outcome after Perinatal Hypoxia-Ischemia: Is the Strong Ion Gap Superior to Base Excess and Lactate?
MedLine Citation:
PMID:  22307844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We conducted this study to compare the strong ion gap (SIG) with base excess (BE) and lactate for predicting neurologic outcome measured by magnetic resonance imaging (MRI) in newborns with hypoxic-ischemic encephalopathy (HIE). In a retrospective cohort of 39 newborns with HIE treated with whole-body surface cooling (n = 17) and no cooling (n = 22), we measured blood SIG, BE, and lactate at 4, 24, and 48 hours after birth, and determined cerebral injury severity by T1-, T2-, and diffusion-weighted MRI scores at age 5 days. Lower SIG levels correlated with better neurologic outcome. The highest correlation coefficient (0.63) was in the "no cooling" subcohort between diffusion-weighted scores and SIG levels at 24 hours; the latter also had the highest area under the receiver operating characteristic curve (AUC), 0.90, with positive and negative predictive values of 84 and 90%. SIG outperformed lactate in the "no cooling" subcohort, and vice-versa in the "cooling" subcohort. All BE AUCs were <0.6. Overall, the SIG is similar to lactate as a prognostic parameter. BE levels at 4, 24, and 48 hours after birth do not predict neurologic outcome. While not displacing lactate the SIG is an additional prognostic parameter for newborns in the first 2 days after hypoxia-ischemia.
Authors:
Christian Mann; Beatrice Latal; Beth Padden; Ianina Scheer; Georg Goebel; Vera Bernet
Related Documents :
18661214 - Analysis of microvascularity after reperfused acute myocardial infarction using the max...
21576784 - Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization ...
19346094 - Predictors of image quality of coronary computed tomography in the acute care setting o...
18055034 - Identification and differentiation of magnetically labeled mesenchymal stem cells in vi...
9706834 - Non-invasive diagnosis of pulmonary embolism.
21414544 - Ultrasound in the diagnosis of noninflammatory musculoskeletal conditions.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  American journal of perinatology     Volume:  -     ISSN:  1098-8785     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Affiliation:
Neonatal and Pediatric Intensive Care Unit, Graubuenden Cantonal Hospital, Chur, and College for Intensive Care, Emergency and Anesthesia Nursing, University Children's Hospital Zurich, Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blunted Heart Rate Circadian Rhythms in Small for Gestational Age Infants during the Early Neonatal ...
Next Document:  Low HCMV DNA Copies Can Establish Infection and Result in Significant Symptoms in Extremely Preterm ...