Document Detail


Acid-Base Jointly Promoted Copper(I)-Catalyzed Azide-Alkyne Cycloaddition.
MedLine Citation:
PMID:  21793533     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this novel acid-base jointly promoted CuAAC, the combination of CuI/DIPEA/HOAc was developed as a highly efficient catalytic system. The functions of DIPEA and HOAc have been assigned, and HOAc was recognized to accelerate the conversions of the C-Cu bond-containing intermediates and buffer the basicity of DIPEA. As a result, all drawbacks occurring in the popular catalytic system CuI/NR(3) were overcome easily.
Authors:
Changwei Shao; Xinyan Wang; Qun Zhang; Sheng Luo; Jichen Zhao; Yuefei Hu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-27
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
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