Document Detail


Achondroplasia and hypochondroplasia. Clinical variation and spinal stenosis.
MedLine Citation:
PMID:  7298674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-eight patients with achondroplasia and 24 with hypochondroplasia have been reviewed in order to clarify the differences between the two disorders and establish the height, body proportions and other clinical and radiological variations within each group. Some of the "classical" findings in achondroplasia are not always present, and hypochondroplasia at its most severe is indistinguishable from achondroplasia at its least severe. The frequency of spinal stenosis and neurological complications was established in an unselected group of 27 achondroplastic and 12 hypochondroplastic patients aged 10 years and over. Only three of the former were free of symptoms but only three developed serious complications (11 per cent). Measurement of radiographs of the lumbar canal did not in general correlate well with the severity of spinal stenosis symptoms, but it was found that the ratio of interpedicular distances at the first and fourth lumbar vertebrae had some value. Neurological complications were rare in patients with simple narrowing of the spinal canal or with persistence of a thoracolumbar kyphos but when these occurred together there was a high risk of serious neurological involvement.
Authors:
R Wynne-Davies; W K Walsh; J Gormley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  63B     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  1981  
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  508-15     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Achondroplasia / complications,  diagnosis*
Adolescent
Body Height
Child
Dwarfism / complications,  diagnosis*
Female
Genetic Variation
Humans
Male
Spinal Canal / radiography
Spinal Cord Compression / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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