| Achieving lipid goals in real life: the Dutch DISCOVERY study. | |
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MedLine Citation:
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PMID: 16351669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DISCOVERY Netherlands was an open-label, randomised, multicentre study (D3560/L00003) designed to compare the effects of rosuvastatin with those of atorvastatin, simvastatin or pravastatin on low-density lipoprotein cholesterol (LDL-C) goal achievement in a primary care setting. Patients (n = 1,215) with type IIa or type IIb hypercholesterolaemia and cardiovascular risk of >20% or a history of coronary heart or other atherosclerotic vascular disease were randomised to receive treatment with rosuvastatin 10 mg (n = 621), atorvastatin 10 mg (n = 189), simvastatin 20 mg (n = 194) or pravastatin 40 mg (n = 211) for 12 weeks. Significantly, more patients achieved 1998 and 2003 European LDL-C goals with rosuvastatin than with other statins after 12 weeks (p < 0.001). Rosuvastatin reduced LDL-C and total cholesterol levels significantly more than other statins, both in patients who were statin-na?ve and in patients who had received previous statin treatment (p < 0.05). All treatments were similarly well tolerated. In conclusion, greater reductions in LDL-C were achieved with rosuvastatin compared with atorvastatin, simvastatin and pravastatin, enabling more patients to achieve European LDL-C goals. |
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Authors:
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A F E Bots; J J P Kastelein; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 59 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-14 Completed Date: 2006-05-25 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 1387-94 Citation Subset: IM |
Affiliation:
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Zuiderhoed General Practice, 's-Hertogenbosch, Amsterdam, the Netherlands. a.bots@zuiderhoed.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Atherosclerosis / blood, prevention & control Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Disease / blood, prevention & control Female Fluorobenzenes / therapeutic use Heptanoic Acids / therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / drug therapy* Male Middle Aged Netherlands Pravastatin / therapeutic use Pyrimidines / therapeutic use Pyrroles / therapeutic use Simvastatin / therapeutic use Sulfonamides / therapeutic use Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fluorobenzenes; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Pyrroles; 0/Sulfonamides; 0/Triglycerides; 110862-48-1/atorvastatin; 287714-41-4/rosuvastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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