Document Detail

Achieving LDL-C target levels: the role of statins.
MedLine Citation:
PMID:  11268713     Owner:  NLM     Status:  MEDLINE    
Epidemiological and clinical studies have clearly established the link between elevated low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD). Consequently, treatment guidelines have been developed that identify LDL-C as a causative factor for CHD and as a target for lipid-lowering therapy. The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are considered the drugs of choice for lowering LDL-C in patients with hypercholesterolaemia. However, despite the proven efficacy of statins in reducing LDL-C, many patients do not achieve recommended LDL-C target levels. Surveys suggest that patients do not receive the appropriate drugs in adequate dosage to reach LDL-C target values. Success in achieving targets is lowest in patients at the highest risk, i.e. those with established CHD. The introduction of more potent HMG-CoA reductase inhibitors, or the use of higher doses of older statins, should allow more patients to achieve LDL-C target levels.
J M Lablanche
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medical research and opinion     Volume:  16     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Service de Cardiologie B et Hemodynamique, Hôpital Cardiologique, 59037 Lille, France.
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MeSH Terms
Anticholesteremic Agents / chemistry,  pharmacology,  therapeutic use*
Cholesterol, LDL / blood*,  drug effects*
Coronary Disease / etiology*,  prevention & control*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / chemistry,  pharmacology,  therapeutic use*
Hypercholesterolemia / complications*,  drug therapy*
Patient Selection
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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