| Achalasia in the elderly. Effects of aging on clinical presentation and outcome. | |
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MedLine Citation:
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PMID: 1988268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and manometric data from 13 elderly subjects with idiopathic achalasia (mean age 79 +/- 2 years) were compared with findings from younger subjects with the same disease (n = 79) to see if aging altered the presentation and outcome of this motor disorder. Fewer elderly subjects complained of chest pain (27% vs 53%), and the pain was significantly less severe (P less than 0.01). Other presenting features (including sex, duration of symptoms, and presence and severity of dysphagia) did not differ between the groups. Across all patients, age weakly and inversely correlated with residual postdeglutitive lower esophageal sphincter; (LES) pressure (R = -0.34), and residual pressure was significantly lower in the older subjects (8.0 +/- 1.3 mm Hg vs. 11.9 +/- 0.8 mm Hg; P = 0.02). No differences in basal LES pressure or esophageal-body contraction amplitudes were present between the groups. Initial success with pneumatic dilation was similar in the two subject groups, but the number of older subjects available for analysis was too small to draw strong conclusions. These results indicate that aging decreases the elevation of LES residual pressure that occurs with achalasia. As elderly achalasia patients also present with less chest pain, the findings may be interrelated. |
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Authors:
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R E Clouse; B K Abramson; J R Todorczuk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 36 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-02-27 Completed Date: 1991-02-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 225-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology* Chest Pain / etiology Esophageal Achalasia / complications, physiopathology*, therapy Esophagogastric Junction / physiopathology Female Humans Male Manometry |
| Grant Support | |
ID/Acronym/Agency:
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AMO7130/AM/NIADDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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