Document Detail


Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: effects of prostaglandin F(2)alpha.
MedLine Citation:
PMID:  18849138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies indicate that acetylsalicylic acid may reduce the risk of mortality due to colon cancers. Metastasis is the major cause of cancer death. Matrix metalloproteinases (MMPs) play important roles in tumor invasion regulation, and prostaglandin F(2)alpha (PGF(2)alpha) is a key stimulator of MMP production. Thus, we investigated whether acetylsalicylic acid regulated MMP activity and the invasion of cancer cells and whether PGF(2)alpha attenuated acetylsalicylic acid-inhibited invasion of cancer cells. Gelatin-based zymography assays showed that acetylsalicylic acid inhibited the MMP-2 activity of B16F0 melanoma cells. Matrigel-based chemoinvasion assays showed that acetylsalicylic acid inhibited the invasion of B16F0 cells. Acetylsalicylic acid can inhibit PGF(2)alpha synthesis and PGF(2)alpha is a key stimulator of MMP-2 production. Our data showed that PGF(2)alpha treatment attenuated the acetylsalicylic acid-inhibited invasion of B16F0 cells. In animal experiments, acetylsalicylic acid reduced colorectal metastasis of B16F0 cells in C57BL/6J mice by 44%. Our results suggest that PGF(2)alpha is a therapeutic target for metastasis inhibition and acetylsalicylic acid may possess anti-metastasis ability.
Authors:
Chin-Shaw Stella Tsai; Shue-Fen Luo; Chung-Chu Ning; Chien-Liang Lin; Ming-Chung Jiang; Ching-Fong Liao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-17
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  63     ISSN:  1950-6007     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  522-7     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticarcinogenic Agents / pharmacology*
Aspirin / pharmacology*
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms / metabolism,  secondary*
Cyclooxygenase Inhibitors / pharmacology*
Dinoprost / metabolism*,  pharmacology
Male
Matrix Metalloproteinase 2 / metabolism*
Melanoma, Experimental / enzymology,  pathology*
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Cyclooxygenase Inhibitors; 50-78-2/Aspirin; 551-11-1/Dinoprost; EC 3.4.24.24/Matrix Metalloproteinase 2

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