| Acetylsalicylic acid reduces perfusion deficit in ischemic injured brain in rats. | |
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MedLine Citation:
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PMID: 14512851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acetylsalicylic acid (ASA) is an antiplatelet agent which has been used in treatment and prevention of stroke in humans. In the present study, the effects of ASA on perfusion deficits in the brain have been studied in an embolic model of stroke. Data showed that perfusion deficits were observed in all rats sacrificed immediately after middle cerebral artery (MCA) occlusion. Treatment with ASA significantly reduced perfusion deficits 1 h but not 3 h after the MCA occlusion. These findings thus support that ASA is useful agent in treatment and prevention of stroke, and show that its mechanism of action is likely through the reopening of cerebral microvessels. |
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Authors:
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Ghias Uddin; Munawar Hussain; Chen Xu Wang; Kathryn G Todd; Ashfaq Shuaib |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 14 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2004-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1753-5 Citation Subset: IM |
Affiliation:
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Stroke Research Laboratory, 533 HRMC, University of Alberta, Edmonton ABT6G 2S2, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / pharmacology* Brain Ischemia / drug therapy*, physiopathology Cerebrovascular Circulation / drug effects* Disease Models, Animal Fibrinolytic Agents / pharmacology* Infarction, Middle Cerebral Artery / drug therapy Intracranial Embolism / drug therapy Male Platelet Aggregation Inhibitors / pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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