| Acetylsalicylic acid may protect the patient by increasing fibrin gel porosity. Is withdrawing of treatment harmful to the patient? | |
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MedLine Citation:
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PMID: 8880021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of acetylsalicylic acid in preventing cardiovascular complications is ascribed to acetylation of the enzyme cyclo-oxygenase thereby inhibiting prostaglandin synthesis. Acetylsalicylic acid, however, also acetylates fibrinogen. In the present pilot study, we investigated the permeability, i.e. porosity, of the fibrin gel in male patients with stable angina pectoris treated with this drug before and at 1 and 2 weeks after withdrawal. Ten patients were treated with 75 mg and eight with 160 mg. The results were compared to those in seven untreated healthy controls. Bleeding times were longer during treatment and were reduced after withdrawal indicating patient compliance. Fibrin gels were more porous during treatment although there were large inter-individual variations in porosity. One week after withdrawal, the porosity was reduced by 30 41%, i.e. the network became tighter (75 mg group P = 0.001; 160 mg group P = 0.002). The tightness was more pronounced after withdrawal than in the untreated controls. In conclusion, the protective effect of acetylsalicylic acid may be ascribed to its effect not only on platelets but also on fibrinogen. The withdrawal of acetylsalicylic acid may clause a markedly reduced fibrin gel porosity that we assume is disadvantageous in patients with cardiovascular disease. |
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Authors:
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K Fatah; H Beving; A Albåge; T Ivert; M Blombäck |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 17 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-01-30 Completed Date: 1997-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1362-6 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Karolinska Hospital/ Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Angina Pectoris / complications, drug therapy*, physiopathology Aspirin / administration & dosage, therapeutic use* Coronary Artery Bypass Coronary Disease / complications, drug therapy, physiopathology Dose-Response Relationship, Drug Fibrin Fibrinogen Degradation Products / drug effects*, metabolism Humans Male Middle Aged Platelet Aggregation Inhibitors / administration & dosage, therapeutic use* Postoperative Complications / prevention & control* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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