Document Detail

Acetylsalicylic acid inhibits the pituitary response to exercise-related stress in humans.
MedLine Citation:
PMID:  11740295     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Prostaglandins (PGs) modulate the activity of the hypothalamus-pituitary axis, and pituitary hormones are largely involved in the physiological responses to exercise. The purpose of this study was to analyze the effects of acetylsalicylic acid (ASA), an inhibitor of PGs synthesis, in the pituitary responses to physical stress in humans. METHODS: Adrenocorticotropin (ACTH), beta-endorphin, cortisol, growth hormone (GH), and prolactin (PRL) responses to exercise were evaluated after administration of either placebo or ASA. Blood samples for hormone evaluations before (-30, -15, and 0 pre) and after (0 post, +15, +30, +45, +60, and +90 min) a 30-min treadmill exercise (75% of .VO(2max)) were taken from 12 male athletes during two exercise trials. One tablet of ASA (800 mg), or placebo, was administered two times daily for 3 d before and on the morning of each exercise-test. RESULTS: The results clearly show that, compared with placebo, ASA ingestion significantly blunted the increased serum ACTH, beta-endorphin, cortisol, and GH levels before exercise (anticipatory response) and was associated with reduced cortisol concentrations after exercise. Furthermore, although no differences in the GH response to exercise were shown, a significantly reduced total PRL response to stress condition was observed after ASA. CONCLUSION: ASA influences ACTH, beta-endorphin, cortisol, GH, and PRL responses to exercise-related stress in humans (preexercise activation/exercise-linked response). Even though it is not possible to exclude direct action for ASA, our data indirectly confirm a role of PGs in these responses. We have to further evaluate the nature of the preexercise endocrine activation and, because of the large use of anti-inflammatory drugs in athletes, whether the interaction between ASA and hormones might positively or negatively influence health status, performance, and/or recovery.
L Di Luigi; L Guidetti; F Romanelli; C Baldari; D Conte
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  33     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2029-35     Citation Subset:  IM; S    
Endocrinology Unit, Laboratory of Endocrine Research, University Institute of Motor Sciences (IUSM), Piazza Lauro de Bosis, 15, 00194 Rome, Italy.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Area Under Curve
Aspirin / pharmacology*
Cross-Over Studies
Dinoprostone / blood
Double-Blind Method
Exercise / physiology*
Growth Hormone / blood
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / drug effects*
Lactic Acid / blood
Prolactin / blood
Prostaglandin Antagonists / pharmacology*
Stress, Physiological / blood*
beta-Endorphin / blood
Reg. No./Substance:
0/Prostaglandin Antagonists; 363-24-6/Dinoprostone; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 50-78-2/Aspirin; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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