| Acetylsalicylic acid--inducer of cytochrome P-450 2E1? | |
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MedLine Citation:
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PMID: 8067899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pretreatment of rats with acetylsalicylic acid or sodium salicylate stimulates the metabolism of dichloromethane to carbon monoxide as measured by the carboxyhemoglobin level in blood. Simultaneous administration of dichloromethane and acetylsalicylic acid or sodium salicylate, respectively, was accompanied by reduced carboxyhemoglobin formation. In liver microsomes of rats pretreated with acetylsalicylic acid the p-nitrophenol hydroxylase activity was increased. It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1. |
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Authors:
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D Pankow; B Damme; K Schrör |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of toxicology Volume: 68 ISSN: 0340-5761 ISO Abbreviation: Arch. Toxicol. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-09-19 Completed Date: 1994-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 261-5 Citation Subset: IM |
Affiliation:
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Institut für Pharmakologie und Toxikologie, Bereich Umwelttoxikologie der Martin-Luther-Universität Halle-Wittenberg, Halle Saale, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / pharmacology* Carboxyhemoglobin / drug effects Cytochrome P-450 CYP2E1 Cytochrome P-450 Enzyme System / biosynthesis, drug effects* Enzyme Induction Male Methylene Chloride / pharmacology Microsomes, Liver / drug effects Mixed Function Oxygenases / drug effects Oxidoreductases, N-Demethylating / biosynthesis, drug effects* Rats Rats, Wistar Salicylic Acid Salicylic Acids / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Salicylic Acids; 50-78-2/Aspirin; 69-72-7/Salicylic Acid; 75-09-2/Methylene Chloride; 9035-51-2/Cytochrome P-450 Enzyme System; 9061-29-4/Carboxyhemoglobin; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Cytochrome P-450 CYP2E1; EC 1.5.-/Oxidoreductases, N-Demethylating |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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