Document Detail


Acetylsalicylic acid--inducer of cytochrome P-450 2E1?
MedLine Citation:
PMID:  8067899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pretreatment of rats with acetylsalicylic acid or sodium salicylate stimulates the metabolism of dichloromethane to carbon monoxide as measured by the carboxyhemoglobin level in blood. Simultaneous administration of dichloromethane and acetylsalicylic acid or sodium salicylate, respectively, was accompanied by reduced carboxyhemoglobin formation. In liver microsomes of rats pretreated with acetylsalicylic acid the p-nitrophenol hydroxylase activity was increased. It is concluded that (i) cytochrome P-450 2E1 is involved in the metabolic conversion of both dichloromethane and salicylic acid, and (ii) salicylic acid may be an inducer of cytochrome P-450 2E1.
Authors:
D Pankow; B Damme; K Schrör
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of toxicology     Volume:  68     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-19     Completed Date:  1994-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
Affiliation:
Institut für Pharmakologie und Toxikologie, Bereich Umwelttoxikologie der Martin-Luther-Universität Halle-Wittenberg, Halle Saale, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / pharmacology*
Carboxyhemoglobin / drug effects
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System / biosynthesis,  drug effects*
Enzyme Induction
Male
Methylene Chloride / pharmacology
Microsomes, Liver / drug effects
Mixed Function Oxygenases / drug effects
Oxidoreductases, N-Demethylating / biosynthesis,  drug effects*
Rats
Rats, Wistar
Salicylic Acid
Salicylic Acids / pharmacology
Chemical
Reg. No./Substance:
0/Salicylic Acids; 50-78-2/Aspirin; 69-72-7/Salicylic Acid; 75-09-2/Methylene Chloride; 9035-51-2/Cytochrome P-450 Enzyme System; 9061-29-4/Carboxyhemoglobin; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Cytochrome P-450 CYP2E1; EC 1.5.-/Oxidoreductases, N-Demethylating

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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