Document Detail


Acetylsalicylic acid-induced gastrointestinal bleeding determined by a 51Cr method on a day-to-day basis.
MedLine Citation:
PMID:  6970979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The daily gastrointestinal blood loss caused by plain and microencapsulated acetylsalicylic acid (ASA) tablets was compared. Fourteen healthy, male volunteers participated in a double-blind, cross-over study, lasting 38 days. Before drug administration a median gastrointestinal bleeding of 0.9 ml/24 h was observed. During oral intake of 1.5 g ASA twice a day for 5 days, an increased faecal blood loss was seen in all volunteers. The increase was significant for both plain and microencapsulated ASA (p less than 0.01). Plain ASA tablets, however, caused a greater faecal blood loss than the microencapsulated tablets (p = 0.05), maximum median levels being 6.2 ml/24 h and 3.9 ml/24 h, respectively. An optimal design of radiochromium studies for determination of drug-induced gastrointestinal blood loss is discussed.
Authors:
J H Dybdahl; L N Daae; S Larsen; H Ekeli; K Frislid; I Wiik; L Aanstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  15     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  887-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspirin / adverse effects*
Chromium Radioisotopes / diagnostic use
Double-Blind Method
Feces / analysis
Gastrointestinal Hemorrhage / chemically induced*
Humans
Male
Middle Aged
Salicylates / blood
Time Factors
Chemical
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Salicylates; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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