Document Detail


Acetylsalicylic acid decreases tau phosphorylation at serine 422.
MedLine Citation:
PMID:  16386371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tau protein pathology in Alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites. One of these sites is serine 422 which modification has been correlated with a possible toxic effect of phosphotau in neural cells. In this work, we have found that in the presence of acetylsalicylic acid, at a concentration like that used for anti-inflammatory treatments, tau phosphorylation at serine 422 decreases.
Authors:
E Tortosa; J Avila; M Pérez
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-28
Journal Detail:
Title:  Neuroscience letters     Volume:  396     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Affiliation:
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy,  metabolism,  physiopathology
Amino Acid Sequence / physiology
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  pharmacology
Aspirin / chemistry,  pharmacology*
Brain / drug effects,  metabolism,  physiopathology
Cell Line, Tumor
Down-Regulation / drug effects,  physiology
Humans
Neurons / drug effects,  metabolism
Phosphorylation / drug effects
Serine / metabolism*
tau Proteins / antagonists & inhibitors*,  drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/tau Proteins; 50-78-2/Aspirin; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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