Document Detail

Acetylsalicylic acid decreases tau phosphorylation at serine 422.
MedLine Citation:
PMID:  16386371     Owner:  NLM     Status:  MEDLINE    
Tau protein pathology in Alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites. One of these sites is serine 422 which modification has been correlated with a possible toxic effect of phosphotau in neural cells. In this work, we have found that in the presence of acetylsalicylic acid, at a concentration like that used for anti-inflammatory treatments, tau phosphorylation at serine 422 decreases.
E Tortosa; J Avila; M Pérez
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-28
Journal Detail:
Title:  Neuroscience letters     Volume:  396     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
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MeSH Terms
Alzheimer Disease / drug therapy,  metabolism,  physiopathology
Amino Acid Sequence / physiology
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  pharmacology
Aspirin / chemistry,  pharmacology*
Brain / drug effects,  metabolism,  physiopathology
Cell Line, Tumor
Down-Regulation / drug effects,  physiology
Neurons / drug effects,  metabolism
Phosphorylation / drug effects
Serine / metabolism*
tau Proteins / antagonists & inhibitors*,  drug effects*,  metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/tau Proteins; 50-78-2/Aspirin; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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