Document Detail


Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo-controlled trial.
MedLine Citation:
PMID:  2681509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 1078 patients admitted to the coronary care unit with acute chest pain, 293 who had possible acute myocardial infarction and symptoms of median 4 h duration were randomized to treatment with acetylsalicylic acid (ASA) 100 mg daily, 1000 mg daily or placebo for 3 months. During hospitalization, the combined incidence of cardiac death and non-fatal myocardial infarction on-treatment (withdrawals not included) was significantly lower (P less than 0.02) in the 100 mg group (7.1%) than in both the 1000 mg group (20.8%) and the placebo group (19.7%). During later time periods of treatment and at all time periods analysed according to the intention-to-treat principle (withdrawals included), data suggested the same trend, but differences were not statistically significant. Collagen-induced platelet aggregation and serum thromboxane B2 were reduced to the same degree in the two ASA groups and were normal in the placebo group. The data suggest that low-dose ASA could be cheap and safe as first-aid therapy in myocardial infarction suspects.
Authors:
S E Husted; H Kraemmer Nielsen; L R Krusell; O Faergeman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  226     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Cardiology, Aarhus Amtssygehus, University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aspirin / administration & dosage*,  adverse effects
Clinical Trials as Topic
Creatine Kinase / blood
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  mortality
Placebos
Platelet Aggregation / drug effects
Random Allocation
Thromboxane B2 / blood*
Chemical
Reg. No./Substance:
0/Placebos; 50-78-2/Aspirin; 54397-85-2/Thromboxane B2; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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