Document Detail

Acetylsalicylate-induced cholestasis, unrelated to biliary bile acid excretion, in the rabbit.
MedLine Citation:
PMID:  3149194     Owner:  NLM     Status:  MEDLINE    
Administration of lysine acetylsalicylate to anaesthetized rabbits induced a marked decrease in bile flow and biliary secretion rates of sodium, potassium, chloride and bicarbonate. Bile acid concentrations were increased but biliary bile acid outputs were similar to those observed in control animals after i.v. injection of saline or lysine. Our results confirm that different species have different susceptibilities to salicylates since in other species this group of drugs is choleretic. It is suggested that the cholestatic effect of acetylsalicylate in the rabbit is due to acetylsalicylate and that it is associated with a reduction in the bile acid-independent bile flow since bile acid outputs remained constant after administration of the drug.
M J Monte; A Esteller; R Jimenez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  47     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1988  
Date Detail:
Created Date:  1989-04-28     Completed Date:  1989-04-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM    
Department of Physiology and Pharmacology, University of Salamanca, Spain.
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MeSH Terms
Analgesics / toxicity*
Aspirin / analogs & derivatives*,  toxicity
Bicarbonates / secretion
Bile / drug effects,  secretion*
Bile Acids and Salts / secretion*
Chlorides / secretion
Cholestasis / chemically induced*
Lysine / analogs & derivatives*,  pharmacology,  toxicity
Potassium / secretion
Reference Values
Sodium / secretion
Reg. No./Substance:
0/Analgesics; 0/Bicarbonates; 0/Bile Acids and Salts; 0/Chlorides; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 56-87-1/Lysine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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