| Acetylsalicylate-induced cholestasis, unrelated to biliary bile acid excretion, in the rabbit. | |
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MedLine Citation:
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PMID: 3149194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of lysine acetylsalicylate to anaesthetized rabbits induced a marked decrease in bile flow and biliary secretion rates of sodium, potassium, chloride and bicarbonate. Bile acid concentrations were increased but biliary bile acid outputs were similar to those observed in control animals after i.v. injection of saline or lysine. Our results confirm that different species have different susceptibilities to salicylates since in other species this group of drugs is choleretic. It is suggested that the cholestatic effect of acetylsalicylate in the rabbit is due to acetylsalicylate and that it is associated with a reduction in the bile acid-independent bile flow since bile acid outputs remained constant after administration of the drug. |
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Authors:
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M J Monte; A Esteller; R Jimenez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 47 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-28 Completed Date: 1989-04-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 767-73 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, University of Salamanca, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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toxicity* Animals Aspirin / analogs & derivatives*, toxicity Bicarbonates / secretion Bile / drug effects, secretion* Bile Acids and Salts / secretion* Chlorides / secretion Cholestasis / chemically induced* Lysine / analogs & derivatives*, pharmacology, toxicity Male Potassium / secretion Rabbits Reference Values Sodium / secretion |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Bicarbonates; 0/Bile Acids and Salts; 0/Chlorides; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 56-87-1/Lysine; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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