| Acetylcholinesterase prophylaxis against organophosphate toxicity. | |
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MedLine Citation:
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PMID: 3653568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal bovine serum acetylcholinesterase (FBS-AChE) protected mice from multiple LD50 doses of organophosphorus (OP) nerve agents. Mice were injected intraperitoneally (ip) with up to 3.3 mg (11,000 U) of FBS-AChE which exhibited a relatively long serum half-life and appeared well tolerated. The enzyme protected mice from the OP ethyl-S-2-diisopropylamino-ethylmethylphosphonothiolate (VX) with a stoichiometry equal to approximately 2 moles of enzyme active site per mole of VX. FBS-AChE, at a lower enzyme OP ratio, protected mice from 2 LD50s of the nerve agent methylphosphonofluoridic acid 1,2,2,-trimethylpropyl ester (soman) when used in conjunction with atropine and 2[(hydroxyimino)methyl]-1-methylpyridinium chloride. It is concluded that sequestration of highly toxic OPs by administration of AChE occurs in mice and suggests a new approach to treatment of OP intoxication. |
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Authors:
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A D Wolfe; R S Rush; B P Doctor; I Koplovitz; D Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 9 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-11-02 Completed Date: 1987-11-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 266-70 Citation Subset: IM |
Affiliation:
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Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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blood,
therapeutic use* Animals Female Lethal Dose 50 Male Mice Mice, Inbred ICR Organophosphorus Compounds / antagonists & inhibitors, toxicity* Organothiophosphorus Compounds / antagonists & inhibitors, toxicity Soman / antagonists & inhibitors, toxicity Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Organophosphorus Compounds; 0/Organothiophosphorus Compounds; 50782-69-9/VX; 96-64-0/Soman; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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