Document Detail

Acetylcholinesterase prophylaxis against organophosphate toxicity.
MedLine Citation:
PMID:  3653568     Owner:  NLM     Status:  MEDLINE    
Fetal bovine serum acetylcholinesterase (FBS-AChE) protected mice from multiple LD50 doses of organophosphorus (OP) nerve agents. Mice were injected intraperitoneally (ip) with up to 3.3 mg (11,000 U) of FBS-AChE which exhibited a relatively long serum half-life and appeared well tolerated. The enzyme protected mice from the OP ethyl-S-2-diisopropylamino-ethylmethylphosphonothiolate (VX) with a stoichiometry equal to approximately 2 moles of enzyme active site per mole of VX. FBS-AChE, at a lower enzyme OP ratio, protected mice from 2 LD50s of the nerve agent methylphosphonofluoridic acid 1,2,2,-trimethylpropyl ester (soman) when used in conjunction with atropine and 2[(hydroxyimino)methyl]-1-methylpyridinium chloride. It is concluded that sequestration of highly toxic OPs by administration of AChE occurs in mice and suggests a new approach to treatment of OP intoxication.
A D Wolfe; R S Rush; B P Doctor; I Koplovitz; D Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  9     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-02     Completed Date:  1987-11-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  266-70     Citation Subset:  IM    
Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
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MeSH Terms
Acetylcholinesterase / blood,  therapeutic use*
Lethal Dose 50
Mice, Inbred ICR
Organophosphorus Compounds / antagonists & inhibitors,  toxicity*
Organothiophosphorus Compounds / antagonists & inhibitors,  toxicity
Soman / antagonists & inhibitors,  toxicity
Species Specificity
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organothiophosphorus Compounds; 50782-69-9/VX; 96-64-0/Soman; EC

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