| Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 12860856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterise the effects of acetylcholinesterase inhibition with pyridostigmine on parasympathetic tone in patients with chronic heart failure (CHF). DESIGN: Prospective randomised, double blind crossover trial. SETTING: University hospital outpatient heart failure clinic. PATIENTS: 20 ambulatory subjects with stable CHF (mean age 55 years, mean ejection fraction 24%). INTERVENTIONS: Oral administration of a single dose of pyridostigmine 30 mg and matching placebo on separate days. MAIN OUTCOME MEASURES: Heart rate recovery at one minute and three minutes after completion of maximal exercise. RESULTS: Heart rate recovery at one minute after exercise was significantly greater after administration of pyridostigmine than after administration of placebo (mean (SEM) 27.4 (3.2) beats/min v 22.4 (2.4) beats/min, p < 0.01). Heart rate recovery at three minutes after exercise did not differ after administration of pyridostigmine and placebo (mean (SEM) 44.4 (3.9) beats/min v 41.8 (3.6) beats/min, NS). Peak heart rate, peak oxygen uptake, peak respiratory exchange ratio, plasma noradrenaline (norepinephrine) concentrations, and plasma brain natriuretic peptide concentrations did not differ after administration of pyridostigmine and placebo. CONCLUSIONS: Acetylcholinesterase inhibition with pyridostigmine increased heart rate recovery at one minute but not at three minutes after exercise. A specific effect of pyridostigmine on heart rate one minute after exercise suggests that pyridostigmine augments parasympathetic tone in patients with CHF. |
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Authors:
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A S Androne; K Hryniewicz; R Goldsmith; A Arwady; S D Katz |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 89 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2003-09-02 Revised Date: 2010-04-29 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 854-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Output, Low / drug therapy*, physiopathology Cholinesterase Inhibitors / therapeutic use* Cross-Over Studies Double-Blind Method Exercise / physiology* Female Heart Rate / drug effects Humans Male Middle Aged Prospective Studies Pyridostigmine Bromide / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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5 MO1 RR00125/RR/NCRR NIH HHS; HL K24-04024/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 101-26-8/Pyridostigmine Bromide |
| Comments/Corrections | |
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