Document Detail


Acetylcholinesterase inhibition by sulphur and selenium heterosubstituted isomers of N,N-diethylcarbamyl choline and carbaryl.
MedLine Citation:
PMID:  3939750     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine sulphur and selenium heterosubstituted isomers of N,N-diethylcarbamylcholine and carbaryl have been prepared and their inhibiting activity towards electric eel acetylcholinesterase (E.C. 3.1.1.7) have been measured. The N,N-diethylcarbamylcholines acted only as reversible inhibitors, i.e. they could not carbamylate the enzyme. The reversible inhibition was of mixed type. Sulphur and selenium substitution had only marginal effects on Ki(0.2-0.3 mM) but reduced the value of K'i. The heterosubstituted carbaryl analogues were, with one exception, found to be irreversible inhibitors, about 100 times less potent than carbaryl.
Authors:
B Lindgren; G Lindgren; E Artursson; G Puu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition     Volume:  1     ISSN:  8755-5093     ISO Abbreviation:  J. Enzym. Inhib.     Publication Date:  1985  
Date Detail:
Created Date:  1989-07-11     Completed Date:  1989-07-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8709734     Medline TA:  J Enzyme Inhib     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
National Defence Research Institute, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbamates / chemical synthesis*,  pharmacology
Carbaryl / analogs & derivatives*,  chemical synthesis*,  pharmacology
Cholinesterase Inhibitors / chemical synthesis*,  pharmacology
Electrophorus
Indicators and Reagents
Kinetics
Chemical
Reg. No./Substance:
0/Carbamates; 0/Cholinesterase Inhibitors; 0/Indicators and Reagents; 63-25-2/Carbaryl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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