Document Detail

Acetylcholinesterase changes in hearts with sinus rhythm and atrial fibrillation.
MedLine Citation:
PMID:  8482484     Owner:  NLM     Status:  MEDLINE    
1. Clinical and experimental evidence suggest that changes in the autonomic tone play a role in the pathogenesis of atrial fibrillation. 2. We have studied the distribution of molecular forms of acetylcholinesterase (AChE) in atrial biopsies obtained from individuals without arrhythmias and in patients with atrial fibrillation. 3. Analysis of the distribution of globular and asymmetric AChE forms, showed a decrease in the amount of the globular forms of biopsies taken from atria during fibrillation. 4. This study is the first attempt to characterize the molecular forms of AChE in the human heart of patients with sinus rhythm and chronic atrial fibrillation.
R A Gonzalez; E O Campos; C Karmelic; S Moran; N C Inestrosa
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  24     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-05-28     Completed Date:  1993-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Department of Cardiology and Cardiovascular Diseases, Faculty of Medicine, Catholic University of Chile, Santiago.
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MeSH Terms
Acetylcholinesterase / metabolism*
Arrhythmia, Sinus / enzymology*
Atrial Fibrillation / enzymology*
Heart Valves / surgery
Myocardium / enzymology*
Vagus Nerve / physiology
Reg. No./Substance:

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