Document Detail


Acetylcholine release in the hippocampus and prelimbic cortex during acquisition of a socially transmitted food preference.
MedLine Citation:
PMID:  21907814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interference with cholinergic functions in hippocampus and prefrontal cortex impairs learning and memory for social transmission of food preference, suggesting that acetylcholine (ACh) release in the two brain regions may be important for acquiring the food preference. This experiment examined release of ACh in the hippocampus and prefrontal cortex of rats during training for social transmission of food preference. After demonstrator rats ate a food with novel flavor and odor, a social transmission of food preference group of rats was allowed to interact with the demonstrators for 30 min, while in vivo microdialysis collected samples for later measurement of ACh release with HPLC methods. A social control group observed a demonstrator that had eaten food without novel flavor and odor. An odor control group was allowed to smell but not ingest food with novel odor. Rats in the social transmission but not control groups preferred the novel food on a trial 48 h later. ACh release in prefrontal cortex, with probes that primarily sampled prelimbic cortex, did not increase during acquisition of the social transmission of food preference, suggesting that training-initiated release of ACh in prelimbic cortex is not necessary for acquisition of the food preference. In contrast, ACh release in the hippocampus increased substantially (200%) upon exposure to a rat that had eaten the novel food. Release in the hippocampus increased significantly less (25%) upon exposure to a rat that had eaten normal food and did not increase significantly in the rats exposed to the novel odor; ACh release in the social transmission group was significantly greater than that of the either of the control groups. Thus, ACh release in the hippocampus but not prelimbic cortex distinguished well the social transmission vs. control conditions, suggesting that cholinergic mechanisms in the hippocampus but not prelimbic cortex are important for acquiring a socially transmitted food preference.
Authors:
P E Gold; R A Countryman; D Dukala; Q Chang
Related Documents :
11298014 - Standardization of in vitro methods.
10336604 - Ige reactivity and cross-reactivity of japanese monkeys (macaca fuscata) to japanese ce...
8368454 - Does guanine concentration in house-dust samples reflect house-dust mite exposure?
15236774 - Dust mites living in human lungs--the cause of asthma?
21983204 - Advertising influences on young children's food choices and parental influence.
863134 - Relationship of the gastrin response to the amount of food ingested in normal subjects.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-08-30
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  96     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  2012-02-22     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-503     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA. pgold@illinois.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine / secretion*
Analysis of Variance
Animals
Association Learning / physiology*
Cholinergic Neurons / secretion*
Chromatography, High Pressure Liquid
Food Preferences*
Hippocampus / secretion*
Imitative Behavior
Limbic System
Male
Microdialysis
Prefrontal Cortex / secretion*
Rats
Grant Support
ID/Acronym/Agency:
AG07648/AG/NIA NIH HHS; DA016951/DA/NIDA NIH HHS; DA024129/DA/NIDA NIH HHS; R01 AG007648-16/AG/NIA NIH HHS; R01 AG007648-17/AG/NIA NIH HHS; R01 AG007648-17S1/AG/NIA NIH HHS; R21 DA024129-02/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
51-84-3/Acetylcholine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review.
Next Document:  Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive ...