Document Detail

Acetylcholine-regulated K+ current remodelling in the atrium after myocardial infarction and valsartan administration.
MedLine Citation:
PMID:  19340355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atrial fibrillation (AF) is a common complication of myocardial infarction (MI). Angiotensin II receptor antagonists prevent the promotion and propagation of AF. However, the activation of the acetylcholine-regulated K(+) current (I(K,ACh)) in the atrium after MI and the effect of valsartan on I(K,ACh) are less understood.
METHODS: Twenty-four adult rabbits were randomly divided into three groups: sham-operated, MI and MI plus valsartan administration (MI+valsartan). The sham-operated group received a median sternotomy without left ventricular coronary artery ligation. Both the MI group and the MI+valsartan group received a median sternotomy followed by ligation of the midpoint of the left ventricular coronary artery. The MI+valsartan group was administered oral valsartan for 12 weeks. After 12 weeks, the initiation of AF was measured by vagal stimulation followed by quick excision of the heart. I(K,ACh) in the left atrial myocardium was measured by the patch clamp technique.
RESULTS: AF was induced in four animals in the MI group, two in the sham-operated and two in the MI+valsartan groups, with the total AF duration expectedly longer in the MI group than in the sham-operated and MI+valsartan groups (38 s versus 9 s and 9 s, respectively). Furthermore, the mean (+/- SEM) density of I(K,ACh) increased significantly more in the left atrial myocardia of the MI group than in the sham-operated and the MI+valsartan groups (-13+/-0.42 pA/pF versus -9+/-0.38 pA/pF and -10+/-0.37 pA/pF, respectively at -100 mV; and 4.1+/-0.28 pA/pF versus 3.1+/-0.27 pA/pF and 3.3+/-0.27 pA/pF, respectively at 20 mV; P<0.05). However, there was no statistically significant difference in I(K,ACh) between the sham-operated group and the MI+valsartan group.
CONCLUSIONS: AF is associated with increased I(K,ACh) after MI. Inhibition of increased IK,ACh may be the mechanism by which valsartan prevents AF following MI.
Qing-yan Zhao; Cong-xin Huang; Hong Jiang; Emmy Okello; Xi Wang; Yan-hong Tang; Geng-shan Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  25     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-04-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e115-8     Citation Subset:  IM    
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
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MeSH Terms
Acetylcholine / pharmacology*
Angiotensin II Type 1 Receptor Blockers / pharmacology*
Atrial Appendage / innervation
Atrial Fibrillation / physiopathology*,  prevention & control
Heart Atria / physiopathology*
Myocardial Infarction / complications
Patch-Clamp Techniques
Potassium Channels / drug effects,  physiology*
Tetrazoles / pharmacology*
Valine / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Potassium Channels; 0/Tetrazoles; 137862-53-4/valsartan; 51-84-3/Acetylcholine; 7004-03-7/Valine

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