Document Detail


Acetylcholine-induced smooth muscle contraction of intrapulmonary small bronchi is augmented in antigen-induced airway hyperresponsive rats.
MedLine Citation:
PMID:  11128046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Smooth muscle responsiveness of intrapulmonary small bronchi obtained from repeatedly antigen-challenged rats was compared with that from control animals to determine whether smooth muscle contractility of peripheral airways is augmented by such repeated challenge. In intact (non-permeabilized) smooth muscles of intrapulmonary bronchi, the acetylcholine (ACh)-induced contractile response was significantly augmented in the repeated challenge group, although 60-mM K+-induced contraction was within the normal level. In beta-escin-permeabilized muscles, no significant difference between groups was observed in the Ca2+-induced contractile responses. Thus, augmented ACh-induced contraction of intact intrapulmonary small bronchial smooth muscle might be, at least in part, due to an enhanced ACh-mediated Ca2+-sensitizing signal.
Authors:
Y Chiba; Y Takada; H Sakai; H Takeyama; M Misawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  84     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan. chiba@hoshi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology*
Analysis of Variance
Animals
Antigens
Bronchi / drug effects,  physiology
Bronchial Hyperreactivity / chemically induced,  physiopathology*
Calcium / metabolism
Male
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects*,  physiology
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antigens; 51-84-3/Acetylcholine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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