Document Detail


Acetylator polymorphism in Alzheimer's disease.
MedLine Citation:
PMID:  8252158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To elucidate whether any relationship exists between genetic acetylator polymorphism and the risk of developing Alzheimer's disease. METHODS: Acetylator polymorphism has been determined, using sulphamethazine, in 54 patients with Alzheimer's disease or senile dementia of Alzheimer type and in 93 age-matched controls. RESULTS: Thirty-one patients (57.4%) and 54 controls (58%) were classified as slow acetylators (non-significant difference). No relation was found between acetylator polymorphism and age at onset of disease and scores of Minimental examination and Blessed, Tomlinson & Roth scale in the group of patients with Alzheimer's disease/senile dementia of Alzheimer type. CONCLUSIONS: Our results do not support the existence of any relationship between acetylator polymorphism and the risk of developing Alzheimer type dementia.
Authors:
J M Ladero; M S Barquero; F Coria; J A Molina; F J Jiménez-Jiménez; J Benítez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of medicine     Volume:  2     ISSN:  1165-0478     ISO Abbreviation:  Eur J Med     Publication Date:  1993 May 
Date Detail:
Created Date:  1994-01-11     Completed Date:  1994-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9209793     Medline TA:  Eur J Med     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  281-3     Citation Subset:  IM    
Affiliation:
Service of Gastroenterology, Hospital Universitario de San Carlos, University Complutense (Department of Medicine), Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Aged
Alzheimer Disease / genetics*,  metabolism*
Female
Humans
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Risk Factors
Sulfamethazine / metabolism
Chemical
Reg. No./Substance:
57-68-1/Sulfamethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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