| Acetylator polymorphism in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 8252158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To elucidate whether any relationship exists between genetic acetylator polymorphism and the risk of developing Alzheimer's disease. METHODS: Acetylator polymorphism has been determined, using sulphamethazine, in 54 patients with Alzheimer's disease or senile dementia of Alzheimer type and in 93 age-matched controls. RESULTS: Thirty-one patients (57.4%) and 54 controls (58%) were classified as slow acetylators (non-significant difference). No relation was found between acetylator polymorphism and age at onset of disease and scores of Minimental examination and Blessed, Tomlinson & Roth scale in the group of patients with Alzheimer's disease/senile dementia of Alzheimer type. CONCLUSIONS: Our results do not support the existence of any relationship between acetylator polymorphism and the risk of developing Alzheimer type dementia. |
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Authors:
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J M Ladero; M S Barquero; F Coria; J A Molina; F J Jiménez-Jiménez; J Benítez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European journal of medicine Volume: 2 ISSN: 1165-0478 ISO Abbreviation: Eur J Med Publication Date: 1993 May |
Date Detail:
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Created Date: 1994-01-11 Completed Date: 1994-01-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9209793 Medline TA: Eur J Med Country: FRANCE |
Other Details:
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Languages: eng Pagination: 281-3 Citation Subset: IM |
Affiliation:
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Service of Gastroenterology, Hospital Universitario de San Carlos, University Complutense (Department of Medicine), Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Aged Alzheimer Disease / genetics*, metabolism* Female Humans Male Middle Aged Phenotype Polymorphism, Genetic Risk Factors Sulfamethazine / metabolism |
| Chemical | |
Reg. No./Substance:
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57-68-1/Sulfamethazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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