Document Detail


Acetylator phenotypes in rheumatoid arthritis patients with or without adverse drug reactions to sodium-aurothiomalate or d-penicillamine.
MedLine Citation:
PMID:  3114874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n = 29) were compared with a group of patients without ADR (n = 30). The frequency of slow acetylators was significantly (p less than 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).
Authors:
S Rantapää Dahlqvist; T Mjörndal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  16     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-19     Completed Date:  1987-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Adult
Aged
Arthritis, Rheumatoid / drug therapy,  genetics*
Chromatography, High Pressure Liquid
Dapsone / metabolism
Female
Gold Sodium Thiomalate / adverse effects*,  metabolism
Humans
Male
Middle Aged
Penicillamine / adverse effects*,  metabolism
Phenotype
Chemical
Reg. No./Substance:
12244-57-4/Gold Sodium Thiomalate; 52-67-5/Penicillamine; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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