Document Detail

Acetylation phenotype and skin complexion.
MedLine Citation:
PMID:  2430405     Owner:  NLM     Status:  MEDLINE    
The relationship of acetylation phenotype to skin complexion was studied in 155 healthy Caucasians. Individuals received 500 mg sulphadimidine at 11.00 p.m.; urine was collected eight hours later. The percentage of acetylated sulphadimidine in urine was measured with high performance liquid chromatography. There was a slight but insignificant preponderance of slow acetylators in the dark skin types. It is concluded that slow acetylation phenotype is not correlated with light skin complexion. Therefore, it is unlikely that acetylation of xenobiotic carcinogens plays a dominant role in melanoma risk.
F H Rampen; H L van der Meeren; L M Stolk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  66     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  334-6     Citation Subset:  IM    
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MeSH Terms
Acetyltransferases / metabolism*
Melanoma / etiology
Skin Neoplasms / etiology
Skin Pigmentation*
Sulfamethazine / metabolism*,  urine
Reg. No./Substance:
57-68-1/Sulfamethazine; EC 2.3.1.-/Acetyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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