Document Detail

Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes.
MedLine Citation:
PMID:  23313487     Owner:  NLM     Status:  Publisher    
Recently, it was reported that naturally occurring pentacyclic triterpenoids such as ursolic acid have anti-adiposity property. We studied if acetyl-keto-β-boswellic acid (AKBA), an established anti-inflammation and anti-cancer pentacyclic triterpenoid which has similar chemical structure to ursolic acid, may modulate adipocyte phenotype. 3T3-L1 murine adipocytes and human subcutaneous adipocytes were treated by AKBA in different concentrations in vitro. AKBA triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes. Further studies revealed that AKBA down-regulated PPAR-γ and C/EBP-α expression in a dose and temporal dependent manner in mature adipocytes. In human adipocytes, AKBA likewise mobilized lipolysis accompanied by down-regulation of PPAR-γ2 expression and loss of phenotypic markers of mature adipocytes.
Jian-Jun Liu; Wan Ching Toy; Sylvia Liu; Anton Cheng; Boon Khim Lim; Tavin Subramaniam; Chee Fang Sum; Su Chi Lim
Related Documents :
24259067 - Role of an acid phosphatase isoenzyme in callus tissue during cytodifferentiation.
16526707 - Quantum chemical analysis of the thermodynamics of 2d cluster formation of n-carboxylic...
18964877 - Preconcentration of lanthanides from natural waters with a lipophilic crown ether carbo...
16865757 - Apoptolidin a: total synthesis and partially glycosylated analogues.
11879047 - Release of ferulic acid from oat hulls by aspergillus ferulic acid esterase and trichod...
21583637 - 13-ethoxy-carbonyl-16-(1-methyl-ethyl)-17,19-dinoratis-15-ene-4,14-dicarboxylic acid mo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  -     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opiu...
Next Document:  Osterix is required for cranial neural crest-derived craniofacial bone formation.