| Acetyl-L-carnitine improves aged brain function. | |
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MedLine Citation:
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PMID: 20590847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of acetyl-L-carnitine (ALCAR), an acetyl derivative of L-carnitine, on memory and learning capacity and on brain synaptic functions of aged rats were examined. Male Fischer 344 rats were given ALCAR (100 mg/kg bodyweight) per os for 3 months and were subjected to the Hebb-Williams tasks and AKON-1 task to assess their learning capacity. Cholinergic activities were determined with synaptosomes isolated from brain cortices of the rats. Choline parameters, the high-affinity choline uptake, acetylcholine (ACh) synthesis and depolarization-evoked ACh release were all enhanced in the ALCAR group. An increment of depolarization-induced calcium ion influx into synaptosomes was also evident in rats given ALCAR. Electrophysiological studies using hippocampus slices indicated that the excitatory postsynaptic potential slope and population spike size were both increased in ALCAR-treated rats. These results indicate that ALCAR increases synaptic neurotransmission in the brain and consequently improves learning capacity in aging rats. |
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Authors:
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Satoru Kobayashi; Machiko Iwamoto; Kazuo Kon; Hatsue Waki; Susumu Ando; Yasukazu Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Geriatrics & gerontology international Volume: 10 Suppl 1 ISSN: 1447-0594 ISO Abbreviation: Geriatr Gerontol Int Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: Japan |
Other Details:
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Languages: eng Pagination: S99-106 Citation Subset: IM |
Affiliation:
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Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Foundation for Research on Aging and Promotion, Sakaecho, Itabashiku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcarnitine
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pharmacology* Aging / physiology Animals Brain / drug effects* Carnitine / analysis Hippocampus / chemistry, metabolism Learning / drug effects Male Maze Learning Memory / drug effects Muscle, Skeletal / chemistry Myocardium / chemistry Rats Rats, Inbred F344 Synaptic Transmission / drug effects Synaptosomes / chemistry Vitamin B Complex / pharmacology* |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 14992-62-2/Acetylcarnitine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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