Document Detail


Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation.
MedLine Citation:
PMID:  10413658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the impact of long-term acetyl-L-carnitine administration on CD4 and CD8 absolute counts, apoptosis, and insulin-like growth factor-1 (IGF-1) serum levels in HIV-1-infected subjects. The generation of cell-associated ceramide and HIV-1 viremia were also investigated. Eleven asymptomatic, HIV-1-infected subjects were treated daily with acetyl-L-carnitine (3 g) for 5 months. Immunologic and virologic measures and safety were monitored at the start of the treatment and then on days 90 and 150. Altogether our findings suggest that acetyl-L-carnitine administration has a substantial impact on the main immunologic abnormality associated with HIV infection, the loss of CD4 cells, by reducing the rate of apoptotic lymphocyte death. The reduction of ceramide generation and the increase of the serum levels of IGF-1, a major survival factor able to protect cells from apoptosis by different stimuli and conditions, could represent two important mechanisms underlying the observed anti-apoptotic effects of acetyl-L-carnitine.
Authors:
L Di Marzio; S Moretti; S D'Alò; F Zazzeroni; S Marcellini; C Smacchia; E Alesse; M G Cifone; C De Simone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  92     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-30     Completed Date:  1999-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-10     Citation Subset:  IM; X    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acetylcarnitine / administration & dosage,  therapeutic use*,  toxicity
Adult
Apoptosis / drug effects
CD4-Positive T-Lymphocytes / cytology
CD8-Positive T-Lymphocytes / cytology
Ceramides / biosynthesis
Dose-Response Relationship, Drug
Growth Hormone / blood
HIV Infections / blood*,  drug therapy*
HIV Seropositivity / drug therapy
HIV-1*
Humans
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / metabolism*
Lymphocytes / cytology
Male
Middle Aged
Serum Albumin / analysis
Chemical
Reg. No./Substance:
0/Ceramides; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Serum Albumin; 14992-62-2/Acetylcarnitine; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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