| Acetyl-CoA carboxylase regulates global histone acetylation. | |
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MedLine Citation:
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PMID: 22580297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool. The first and rate-limiting reaction in de novo synthesis of fatty acids is carboxylation of acetyl-CoA to form malonyl-CoA, catalyzed by acetyl-CoA carboxylase. In yeast Saccharomyces cerevisiae, acetyl-CoA carboxylase is encoded by the ACC1 gene. In this study, we show that attenuated expression of ACC1 results in increased acetylation of bulk histones, globally increased acetylation of chromatin histones, and altered transcriptional regulation. Together, our data indicate that Acc1p activity regulates the availability of acetyl-CoA for histone acetyltransferases, thus representing a link between intermediary metabolism and epigenetic mechanisms of transcriptional regulation. |
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Authors:
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Luciano Galdieri; Ales Vancura |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-05-11 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 287 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-09 Completed Date: 2012-10-09 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 23865-76 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, St John's University, Queens, New York 11439, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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genetics,
metabolism* Acetylation Blotting, Western Chromatin / drug effects, genetics, metabolism Doxycycline / pharmacology Gene Expression Regulation, Enzymologic / drug effects Gene Expression Regulation, Fungal / drug effects Histone Acetyltransferases / genetics, metabolism Histones / metabolism* Mutation Reverse Transcriptase Polymerase Chain Reaction Saccharomyces cerevisiae / genetics, growth & development, metabolism* Saccharomyces cerevisiae Proteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM087674/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Histones; 0/Saccharomyces cerevisiae Proteins; 564-25-0/Doxycycline; EC 2.3.1.48/Histone Acetyltransferases; EC 6.4.1.2/Acetyl-CoA Carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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