Document Detail

Acetyl-CoA carboxylase regulates global histone acetylation.
MedLine Citation:
PMID:  22580297     Owner:  NLM     Status:  MEDLINE    
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool. The first and rate-limiting reaction in de novo synthesis of fatty acids is carboxylation of acetyl-CoA to form malonyl-CoA, catalyzed by acetyl-CoA carboxylase. In yeast Saccharomyces cerevisiae, acetyl-CoA carboxylase is encoded by the ACC1 gene. In this study, we show that attenuated expression of ACC1 results in increased acetylation of bulk histones, globally increased acetylation of chromatin histones, and altered transcriptional regulation. Together, our data indicate that Acc1p activity regulates the availability of acetyl-CoA for histone acetyltransferases, thus representing a link between intermediary metabolism and epigenetic mechanisms of transcriptional regulation.
Luciano Galdieri; Ales Vancura
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-11
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  287     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-09     Completed Date:  2012-10-09     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23865-76     Citation Subset:  IM    
Department of Biological Sciences, St John's University, Queens, New York 11439, USA.
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MeSH Terms
Acetyl-CoA Carboxylase / genetics,  metabolism*
Blotting, Western
Chromatin / drug effects,  genetics,  metabolism
Doxycycline / pharmacology
Gene Expression Regulation, Enzymologic / drug effects
Gene Expression Regulation, Fungal / drug effects
Histone Acetyltransferases / genetics,  metabolism
Histones / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Saccharomyces cerevisiae / genetics,  growth & development,  metabolism*
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/Saccharomyces cerevisiae Proteins; 564-25-0/Doxycycline; EC Acetyltransferases; EC Carboxylase

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