| Acetonaemia as an initial criterion of evaluation of a probable cause of sudden death. | |
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MedLine Citation:
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PMID: 18849183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The archived head-space chromatograms of ethanol determinations in autopsy blood in the years 1996-2003 were analysed. One hundred and two cases with elevated acetone level >250mmol/l were selected in which the biochemical profiles of volatile alcohols (methanol, isopropanol and n-propanol) were determined after "post-hoc" calibration of the constant internal standard. Based on the files obtained from the Prosecutor's Office, the circumstances of death and those preceding death (alcoholism, prolonged or single consumption of alcohol, intoxications with other substances, hypothermia, undernourishment, diabetes) were analysed and the most probable cause of endogenous or exogenous ketonaemia were determined. All cases of unexplained deaths in alcoholics with the ethanol concentration <0.4g/l occurred after withdrawal of long-term consumption of alcohol while all alcoholics with the ethanol concentration >0.4g/l died during the so-called drinking bout. In the group of hypothermia-related deaths with ethanol concentrations <0.4g/l, the acetone concentration was statistically significantly higher than that in hypothermia group with ethanol concentration >0.4g/l in which "congeneric" concentrations of methanol and isopropanol were additionally observed. Furthermore, an algorithm of further diagnostic management was suggested to distinguish the most likely origin of acetonaemia, i.e. accumulation of exogenous "denaturants" of alcohol consumed and cases of endogenous ketogenesis. |
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Authors:
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Grzegorz Teresi??ski; Grzegorz Buszewicz; Roman Madro |
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Publication Detail:
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Type: Journal Article Date: 2008-10-11 |
Journal Detail:
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Title: Legal medicine (Tokyo, Japan) Volume: 11 ISSN: 1873-4162 ISO Abbreviation: Leg Med (Tokyo) Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889186 Medline TA: Leg Med (Tokyo) Country: Ireland |
Other Details:
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Languages: eng Pagination: 18-24 Citation Subset: IM |
Affiliation:
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Department of Forensic Medicine, Medical University of Lublin, Lublin, Poland. g.teresinski@am.lublin.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Propanol
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blood Alcoholic Intoxication / blood Cause of Death Death, Sudden / etiology* Ethanol / blood Forensic Toxicology Humans Hypothermia / blood Ketone Bodies / blood* Methanol / blood Poisoning / blood |
| Chemical | |
Reg. No./Substance:
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0/Ketone Bodies; 64-17-5/Ethanol; 67-56-1/Methanol; 67-63-0/2-Propanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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