| Acetogenic fibers reduce fasting glucose turnover but not peripheral insulin resistance in metabolic syndrome patients. | |
| | |
MedLine Citation:
|
PMID: 20584565 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: The acute ingestion of an acetogenic indigestible carbohydrate (lactulose) increased acetate turnover associated with decreased lipolysis (glycerol turnover) in insulin-resistant patients. It is not known whether a decreased lipolysis by chronic ingestion of acetogenic indigestible carbohydrates or fibers improves glucose turnover and insulin sensitivity. METHODS: Twenty-one men with metabolic syndrome ingested daily standardized drinks, with or without 28 g acetogenic fibers (acacia gum and pectin), for 5 weeks in a randomized double-blind crossover controlled study design. Euglycaemic-hyperinsulinaemic (EH) clamps coupled with kinetic studies were performed in the fasting state after treatments. RESULTS: Flatulence was more frequent with fiber treatment. Body weight, lipids as well as acetate and glycerol turnovers were unchanged. Fasting endogenous glucose turnover was improved after fiber treatment (7.9 ± 1.3 μmol kg(-1) min(-1)) compared with control (8.6 ± 1.6 μmol kg(-1) min(-1), P < 0.05). But insulin sensitivity (glucose infusion rate) during the EH clamp was not different at the end of fiber and control treatments, 3.7 ± 1.8 and 3.8 ± 1.5 mg kg(-1) min(-1), respectively, nor fasting plasma glucose and insulin. CONCLUSIONS: The chronic ingestion of acacia gum and pectin fibers did not decrease lipolysis but improved fasting endogenous glucose turnover with no effect on peripheral insulin resistance in metabolic syndrome patients. |
| | |
Authors:
|
Etienne Pouteau; Véronique Ferchaud-Roucher; Yassine Zair; Morine Paintin; Marc Enslen; Nicolas Auriou; Katherine Macé; Jean-Philippe Godin; Olivier Ballèvre; Michel Krempf |
Related Documents
:
|
981955 - Arterial-hepatic vein glucose differences in normal and diabetic man after a glucose in... 10547215 - Effects of the amylin analogue pramlintide on hepatic glucagon responses and intermedia... 16355685 - Repeatability of 2 methods for assessment of insulin sensitivity and glucose dynamics i... 22518355 - Factors contributing to non-compliance among diabetics attending primary health centers... 22237685 - Deletion of c/ebp homologous protein (chop) in c57bl/6 mice dissociates obesity from in... 16208735 - Boron nanotubes. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-02 |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: 29 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 801-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Ltd. |
Affiliation:
|
Nestlé Research Centre, P.O. Box 44, Vers-Chez-Les-Blanc, 1000 Lausanne 26, Switzerland. etienne.pouteau@rdls.nestle.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Body fluid retention and body weight change in anorexia nervosa patients during refeeding.
Next Document: Perfluorinated compounds in the Antarctic region: Ocean circulation provides prolonged protection fr...