Document Detail


Acetazolamide and exercise in sojourners to 6,300 meters--a preliminary study.
MedLine Citation:
PMID:  4068966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the effect of acetazolamide on resting acid-base balance and on exercise performance at extreme altitude, we studied four members of the American Medical Research Expedition to Mount Everest at an altitude of 6,300 meters. After an initial progressive exercise test to exhaustion on a bicycle ergometer, subjects were re-studied after taking acetazolamide 250 mg every 8 h for three doses. We measured venous blood during rest for determination of hemoglobin, hematocrit, 2,3-diphosphoglycerate (DPG), bicarbonate, pH, P50, and arterial oxygen saturation by ear oximeter. The results showed that pH, bicarbonate, and DPG:hemoglobin ratio were lower on acetazolamide, whereas P50 at in vivo conditions was unchanged. Exercise ventilation and oxygen consumption for the same workload were slightly higher after acetazolamide, whereas VCO2/VO2 respiratory exchange ratio (R) was lower, and oxygen saturation was unchanged. Two of four subjects had decreased time at maximum workload on acetazolamide; none had an increased performance. The results of this study show that partial carbonic anhydrase inhibition in individuals sojourning to very high altitude produces a further base deficit and a metabolic acidosis, stimulates ventilation, and may impair maximum exercise performance. Although acetazolamide effectively prevents acute mountain sickness, it does not improve performance, and may even impair exercise performance at extreme altitude.
Authors:
P H Hackett; R B Schoene; R M Winslow; R M Peters; J B West
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  17     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  593-7     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology*
Acid-Base Equilibrium / drug effects*
Acidosis / chemically induced
Adult
Altitude*
Heart Rate / drug effects
Hemoglobins / analysis
Humans
Male
Middle Aged
Oxygen Consumption / drug effects
Physical Exertion*
Respiration / drug effects
Grant Support
ID/Acronym/Agency:
HL-24335/HL/NHLBI NIH HHS; HL-26533/HL/NHLBI NIH HHS; N01-HR-2915/HR/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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