Document Detail


Acetazolamide and chronic hypoxia: effects on hemorheology and pulmonary hemodynamics.
MedLine Citation:
PMID:  22523353     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We tested the effect of acetazolamide on blood mechanical properties and pulmonary vascular resistance (PVR) during chronic hypoxia.Six groups of rats treated or not with acetazolamide (Curative = treated after 10 days of hypoxic exposure, Preventive = treated before hypoxic exposure, 40 mg·kg(-1)·day(-1)) and exposed or not to 3 weeks of hypoxia (5,500 m) were used to assess the role of acetazolamide on pulmonary artery pressure, cardiac output, blood volume, hematological and hemorheological parameters.Chronic hypoxia increased hematocrit, blood viscosity and PVR, and decreased cardiac output. acetazolamide treatment in hypoxic rats decreased hematocrit (Curative -10%, Preventive -11%), PVR (Curative -36%, Preventive -49%) and right ventricular hypertrophy (Preventive -20%), and increased cardiac output (Curative +60%, Preventive +115%). Blood viscosity was significantly decreased after curative acetazolamide (-16%) and was correlated with PVR (r=0.87, P<0.05) suggesting that blood viscosity could influence pulmonary hemodynamics. The fall in pulmonary vascular hindrance (Curative -27%, Preventive -45%) after treatment suggests that acetazolamide could decrease pulmonary vessels remodeling under chronic hypoxia.The effect of acetazolamide is multifactorial by acting on erythropoiesis, pulmonary circulation, hemorheological properties and cardiac output, and could represent a pertinent treatment of chronic mountain sickness.
Authors:
Aurélien Pichon; Philippe Connes; Patricia Quidu; Dominique Marchant; Julien Brunet; Bernard I Levy; José Vilar; Innocent Safeukui; Florence Cymbalista; Maxime Maignan; Jean-Paul Richalet; Fabrice Favret
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratoire «Réponses cellulaires et fonctionnelles à l'hypoxie» EA2363, Bobigny, France.
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