Document Detail


Acetazolamide and exercise hypoxia.
MedLine Citation:
PMID:  20419621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acetazolamide is useful for acclimatizing to high altitude. How long it should be taken, and the physiological consequences of stopping it have not been thoroughly studied. We investigated the effect of acetazolamide cessation on exercise oxygenation at different altitudes and durations of use. Three groups were studied: group 1 acclimatized to 4,060 m for 6 days while taking acetazolamide 250 mg three times a day. On day 7 acetazolamide was stopped, then resumed on day 8. Standardized exercise oximetry was performed each day. The protocol for group 2 was identical to group 1, except acclimatization occurred over 14 days to 4 120 m. The protocol for group 3 was identical to group 2, except subjects acclimatized to 4,770 m. Multivariate regression revealed a negative effect of stopping acetazolamide on exercise oxygenation (p=0.028). At 4,100 m cessation of acetazolamide after one week resulted in a 11% drop in exercise oxygenation (p=0.008); after two weeks acclimatization to this altitude there was an non-significant drop in exercise oxygenation (2.5% p=0.064). At 4 770 m acetazolamide cessation resulted in an increase in exercise oxygenation (7% p=0.027). We conclude that exercise oxygenation after acetazolamide cessation is dependent both on duration of acclimatization/drug administration, and acclimatization altitude.
Authors:
J E Lafleur; D Bartniczuk; A Collier; N Griffin; E R Swenson
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-04-23
Journal Detail:
Title:  International journal of sports medicine     Volume:  31     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
Affiliation:
Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. johnelafleur@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / drug effects
Acetazolamide / therapeutic use*
Adult
Anoxia / prevention & control*
Carbonic Anhydrase Inhibitors / therapeutic use*
Exercise / physiology*
Female
Humans
Male
Middle Aged
Peru
Chemical
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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