Document Detail


Acetaminophen protects against iron-induced cardiac damage in gerbils.
MedLine Citation:
PMID:  17311866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are few effective agents that safely remove excess iron from iron-overloaded individuals. Our goal was to evaluate the iron-removing effectiveness of acetaminophen given ip or orally in the gerbil iron-overload model. Male gerbils were divided into 5 groups: saline controls, iron-overloaded controls, iron-overloaded treated with ip acetaminophen, iron-overloaded treated with oral acetaminophen, and iron-overloaded treated with ipdeferoxamine. Iron dextran was injected iptwice/wk for 8 wk. Acetaminophen and deferoxamine treatments were given on Mondays, Wednesdays, and Fridays during the same 8 wk and continued for 4 wk after completion of iron-overloading. Echocardiograms were performed after completion of the iron-overloading and drug treatments. Liver and cardiac iron contents were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Iron-overloaded controls had 232-fold and 16-fold increases in liver and cardiac iron content, respectively, compared to saline controls. In iron-overloaded controls, echocardiography showed cardiac hypertrophy, right and left ventricular distension, significant reduction in left ventricular ejection fraction (-22%), and fractional shortening (-31%) during systole. Treatments with acetaminophen (ip or oral) or deferoxamine (ip) were equally effective in reducing cardiac iron content and in preventing cardiac structural and functional changes. Both agents also significantly reduced excess hepatic iron content, although acetaminophen was less effective than deferoxamine. The results suggest that acetaminophen may be useful for treatment of iron-induced pathology.
Authors:
Ernest M Walker; Christopher P Epling; Cordel Parris; Silvestre Cansino; Protip Ghosh; Devashish H Desai; Ryan G Morrison; Gary L Wright; Paulette Wehner; Elsa I Mangiarua; Sandra M Walker; Eric R Blough
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  37     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-21     Completed Date:  2007-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-33     Citation Subset:  IM    
Affiliation:
Pathology Department, Marshall University Medical School, 1542 Spring Valley Drive, Huntington, WV 25704, USA. walkere@marshall.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / administration & dosage,  metabolism,  therapeutic use*
Administration, Oral
Analysis of Variance
Animals
Body Weight
Echocardiography
Gerbillinae
Heart Diseases / etiology*,  pathology,  prevention & control*
Injections, Intraperitoneal
Iron / metabolism*
Iron Overload / complications*
Liver / metabolism,  pathology
Male
Myocardium / pathology
Organ Size
Specific Pathogen-Free Organisms
Spectrophotometry, Atomic
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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