| Acetaminophen and myocardial infarction in dogs. | |
| | |
MedLine Citation:
|
PMID: 15256373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs. Two groups were studied: vehicle- (n=10) and acetaminophen-treated (n=10) dogs. All dogs were obtained from the same vendor, and there were no significant differences in their ages (18 +/- 2 mo), weights (24 +/- 1 kg), or housing conditions. Selected physiological data, e.g., coronary blood flow, nonspecific collateral flow, epicardial temperature, heart rate, systemic mean arterial pressure, left ventricular developed pressure, the maximal first derivative of left ventricular developed pressure, blood gases, and pH, were collected at baseline and during regional myocardial ischemia and reperfusion. There were no significant differences in coronary blood flow, nonspecific collateral flow, epicardial temperature, heart rate, systemic mean arterial pressure, or blood gases and pH between the two groups at any of the three time intervals, even though there was a trend toward improved function in the presence of acetaminophen. Infarct size, the main objective of the investigation, was markedly and significantly reduced by acetaminophen. For example, when expressed as a percentage of ventricular wet weight, infarct size was 8 +/- 1 versus 3 +/- 1%(P <0.05) in vehicle- and acetaminophen-treated hearts, respectively. When infarct size was expressed as percentage of the area at risk, it was 35 +/- 3 versus 13 +/- 2% (P <0.05) in vehicle- and acetaminophen-treated groups, respectively. When area at risk was expressed as percentage of total ventricular mass, there were no differences in the two groups. Results reveal that the recently reported cardioprotective properties of acetaminophen in vitro can now be extended to the in vivo arena. They suggest that it is necessary to add acetaminophen to the growing list of pharmaceuticals that possess cardioprotective efficacy in mammals. |
| | |
Authors:
|
Gary F Merrill; Tyler H Rork; Norell M Spiler; Roseli Golfetti |
Related Documents
:
|
3608113 - Effects of selectively altering collateral driving pressure on regional perfusion and f... 1621833 - Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium. 16381183 - Relative importance of hypertension compared with hypervolemia for increasing cerebral ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-07-15 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 287 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-10-11 Completed Date: 2004-11-24 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1913-20 Citation Subset: IM |
Affiliation:
|
Department of Cell Biology and Neurosciences, Division of Life Sciences, Rutgers Univ., 604 Allison Rd., Piscataway, NJ 08854, USA. merrill@biology.rutgers.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetaminophen
/
pharmacology* Animals Cardiotonic Agents / pharmacology* Collateral Circulation / drug effects Coronary Circulation / drug effects Dogs Electrocardiography Heart Rate / drug effects Hemodynamics / drug effects Male Microscopy, Electron Myocardial Infarction / pathology*, physiopathology Myofibrils / ultrastructure Necrosis Ventricular Function / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunctio...
Next Document: Loss of atrial contractility is primary cause of atrial dilatation during first days of atrial fibri...