Document Detail

Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse.
MedLine Citation:
PMID:  11397560     Owner:  NLM     Status:  MEDLINE    
Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential of acetaminophen using the immature female mouse model. Specifically, C57Bl/6 female mice were treated with acetaminophen (100, 200 and 250 mg/kg per day, i.p.) for 3 consecutive days. Positive controls received estradiol (10 microg/kg per day, i.p.) for 3 consecutive days. Markers of estrogenic activity examined were uterine weight, uterine peroxidase activity and progesterone receptor (PR) up-regulation. The results demonstrated that, at all three doses, acetaminophen did not significantly increase uterine weight, uterine peroxidase activity or PR levels. However, the co-administration of E(2) and acetaminophen (200 mg/kg per day, 3 days, i.p.) resulted in a decrease in the E(2)-induced upregulation of uterine and hepatic nuclear PR (uterine PR values of 39.7+/-6.6 and 23.7+/-3.4 fmol/mg for E(2)+vehicle and E(2)+acetaminophen, respectively, P<0.05). Additionally, the estradiol-induced increase in uterine peroxidase was decreased 75% by acetaminophen (200 mg/kg per day, 3 days, i.p.). Therefore, in the immature mouse model acetaminophen treatment did not elicit estrogenic activity. However, acetaminophen had a limited ability to antagonize the effects of E(2).
R Patel; R J Rosengren
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  122     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
Department of Pharmacology, Drug Metabolism Group, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand.
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MeSH Terms
Acetaminophen / pharmacology*
Alanine Transaminase / blood,  drug effects
Dose-Response Relationship, Drug
Estradiol / pharmacology
Estrogen Receptor Modulators / pharmacology*
Estrogens / pharmacology*
Injections, Intraperitoneal
Liver / growth & development
Mice, Inbred C57BL
Organ Size / drug effects
Peroxidase / drug effects,  metabolism
Receptors, Progesterone / drug effects,  metabolism
Uterus / growth & development,  metabolism
Reg. No./Substance:
0/Estrogen Receptor Modulators; 0/Estrogens; 0/Receptors, Progesterone; 103-90-2/Acetaminophen; 50-28-2/Estradiol; EC; EC Transaminase

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