Document Detail


Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis.
MedLine Citation:
PMID:  22480579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.
Authors:
Julien Dumont; Arshad Desai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-03
Journal Detail:
Title:  Trends in cell biology     Volume:  22     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-08-15     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. dumont@ijm.univ-paris-diderot.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Centrosome*
Chromosome Segregation*
Humans
Meiosis*
Microtubules
Oocytes / cytology*
Grant Support
ID/Acronym/Agency:
GM074215/GM/NIGMS NIH HHS; R01 GM074215/GM/NIGMS NIH HHS; R01 GM074215-07/GM/NIGMS NIH HHS
Comments/Corrections

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