Document Detail


Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis.
MedLine Citation:
PMID:  22480579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.
Authors:
Julien Dumont; Arshad Desai
Related Documents :
24270699 - C-banded wheat chromosomes in wheat and triticale.
23318629 - Understanding chromatin and chromosomes: from static views to dynamic thinking.
8782429 - Analysis of hya locus in b10.br males with partial deletion of the y chromosome.
24736529 - Delimiting the origin of a b chromosome by fish mapping, chromosome painting and dna se...
24099389 - Development of a genetic linkage map for sharon goatgrass (aegilops sharonensis) and ma...
436449 - Meiotic studies of translocations causing male sterility in the mouse. ii. double heter...
17461809 - The hair collar sign as a marker for neural tube defects.
10856969 - The kinetics of postirradiation chromatin restitution as revealed by chromosome aberrat...
8521729 - Independent chromosome segregation and absence of interchromosomal effect at first meio...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-03
Journal Detail:
Title:  Trends in cell biology     Volume:  22     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-08-15     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. dumont@ijm.univ-paris-diderot.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Centrosome*
Chromosome Segregation*
Humans
Meiosis*
Microtubules
Oocytes / cytology*
Grant Support
ID/Acronym/Agency:
GM074215/GM/NIGMS NIH HHS; R01 GM074215/GM/NIGMS NIH HHS; R01 GM074215-07/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagn...
Next Document:  Argumentation logic for the flexible enactment of goal-based medical guidelines.