| Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis. | |
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MedLine Citation:
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PMID: 22480579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models. |
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Authors:
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Julien Dumont; Arshad Desai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-04-03 |
Journal Detail:
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Title: Trends in cell biology Volume: 22 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-07 Completed Date: 2012-08-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 241-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. dumont@ijm.univ-paris-diderot.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Centrosome* Chromosome Segregation* Humans Meiosis* Microtubules Oocytes / cytology* |
| Grant Support | |
ID/Acronym/Agency:
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GM074215/GM/NIGMS NIH HHS; R01 GM074215/GM/NIGMS NIH HHS; R01 GM074215-07/GM/NIGMS NIH HHS |
| Comments/Corrections | |
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