Document Detail

Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial.
MedLine Citation:
PMID:  10326343     Owner:  NLM     Status:  MEDLINE    
Aloe vera has been used for centuries as a topical treatment for various conditions and as a cathartic. An amorphous hydrogel dressing derived from the aloe plant (Carrasyn Gel Wound Dressing, Carrington Laboratories, Inc., Irving, TX) is approved by the Food and Drug Administration for the management of Stages I through IV pressure ulcers. To evaluate effectiveness of this treatment, 30 patients were randomized to receive either daily topical application of the hydrogel study dressing (acemannan hydrogel wound dressing) or a moist saline gauze dressing. Complete healing of the study ulcer occurred in 19 of 30 subjects (63%) during the 10-week observation period. No difference was observed in complete healing between the experimental and the control groups (odds ratio 0.93, 95% CI 0.16, 5.2). This study indicates that the acemannan hydrogel dressing is as effective as, but is not superior to, a moist saline gauze wound dressing for the management of pressure ulcers.
D R Thomas; P S Goode; K LaMaster; T Tennyson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in wound care : the journal for prevention and healing     Volume:  11     ISSN:  1076-2191     ISO Abbreviation:  Adv Wound Care     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9432971     Medline TA:  Adv Wound Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  N    
Department of Internal Medicine, St. Louis University, MO, USA.
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MeSH Terms
Adjuvants, Immunologic / therapeutic use*
Aged, 80 and over
Hydrogels / therapeutic use*
Mannans / therapeutic use*
Middle Aged
Plant Extracts / therapeutic use*
Pressure Ulcer / drug therapy*
Sodium Chloride / therapeutic use*
Wound Healing
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Hydrogels; 0/Mannans; 0/Plant Extracts; 110865-83-3/acemannan; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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