Document Detail

Acellular dermal matrices in hand reconstruction.
MedLine Citation:
PMID:  23096981     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The goal of this article is to review the current literature on the use of acellular dermal matrix in forearm, wrist, and hand reconstruction.
METHODS: A comprehensive literature search was performed using the Cochrane Database of Systematic Reviews, MEDLINE, PubMed, and Web of Knowledge. Articles were categorized as acellular dermal matrix used in soft-tissue repair and in ligament reconstruction. Search terms included "acellular dermal matrix," "biologic dressing," "skin replacement," "dermal allograft," "AlloDerm," "FlexHD," "Permacol," and "Strattice." These were all cross-referenced with "forearm," "wrist," and "hand." Data extraction focused on indications, surgical techniques, clinical outcomes, and complications. Exclusion criteria included regeneration templates, neonatal foreskin, and review articles.
RESULTS: More than 100 articles published between 1994 and 2011 were identified. Upon final review, five prospective case-control studies, three retrospective case-control studies, four case reports, one cross-sectional cohort, one prospective consecutive series, and one study type unknown were evaluated. Matrix was most commonly used in burn reconstruction. It has also been used in ligament and joint reconstruction for first carpometacarpal arthritis. One article illustrated the use of porcine matrix in basal joint arthritis, a practice that was abruptly terminated because of a concern over increased infections.
CONCLUSIONS: The clinical indications for acellular dermal matrix have increased throughout the last 15 years. Hand surgeons have been cautious but diligent in developing alternative treatment options in hand reconstruction, with a focused effort to reduce donor-site morbidity. Although acellular dermal matrices continue to find innovative uses to solve upper extremity surgical problems, more comparative prospective trials are needed.
Chandra V Ellis; David A Kulber
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  130     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-24     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256S-69S     Citation Subset:  AIM; IM    
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MeSH Terms
Acellular Dermis*
Arthritis / surgery
Biological Dressings
Burns / surgery
Carpometacarpal Joints / surgery
Collagen / therapeutic use
Contracture / surgery
Cross-Sectional Studies
Dupuytren Contracture / surgery
Hand / surgery*
Hand Deformities, Acquired / surgery
Hand Deformities, Congenital / surgery
Hand Injuries / surgery
Ligaments / surgery
Neuralgia / surgery
Prospective Studies
Reconstructive Surgical Procedures / methods*
Retrospective Studies
Skin, Artificial
Surgical Flaps
Reg. No./Substance:
0/Alloderm; 0/Permacol; 0/strattice; 9007-34-5/Collagen
Comment In:
Plast Reconstr Surg. 2013 Oct;132(4):677e-679e   [PMID:  24076726 ]
Plast Reconstr Surg. 2013 Oct;132(4):679e-680e   [PMID:  24076727 ]
Erratum In:
Plast Reconstr Surg. 2012 Dec;130(6):1399

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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