Document Detail

Aceclidine, brimonidine tartrate, and dapiprazole: comparison of miotic effect and tolerability under different lighting conditions.
MedLine Citation:
PMID:  19101423     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effect of 3 types of topically applied miotic eyedrops on the pupil diameter in normal eyes. SETTING: Department of Neurosciences, Section of Ophthalmology, University of Pisa, Pisa, Italy. METHODS: This prospective study comprised 60 eyes of 30 healthy volunteers treated with aceclidine 0.02%, brimonidine tartrate 0.20%, and dapiprazole 0.25%. Pupil diameter was measured under scotopic, mesopic (4 lux), and photopic (50 lux) conditions using an infrared pupillometer incorporated into a CSO topographer. The first measurement was obtained before single instillation of 1 type of miotic eyedrop. Subsequent measurements were taken after 30, 120, and 240 minutes. Each additional medication was tested after an interval of at least 6 weeks to avoid possible effects from the previously administered drug. All patients received a questionnaire and were asked to grade the tolerability of each eyedrop using a subjective scoring system. RESULTS: Aceclidine 0.02% had no significant miotic effect. Brimonidine tartrate 0.20% caused significant miosis within 30 minutes and 120 minutes; after 240 minutes, the effect under all luminance conditions decreased to baseline levels without reaching the initial level. Dapiprazole 0.25% had a miotic effect similar to that of brimonidine but produced many side effects including hyperemia and burning, which many patients said caused significant discomfort. CONCLUSIONS: Brimonidine tartrate 0.20% had the best miotic effect of the 3 agents tested and was well tolerated by the patients. The reproducible miotic effect of brimonidine tartrate under all lighting conditions might benefit postoperative refractive patients who report night-vision difficulties related to large pupils.
Annalisa Canovetti; Marco Nardi; Michele Figus; Paolo Fogagnolo; Umberto Benelli
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  35     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-03-05     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
Department of Neurosciences, Section of Ophthalmology, University of Pisa, Pisa, Italy.
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MeSH Terms
Adrenergic alpha-Agonists / adverse effects,  pharmacology
Adrenergic alpha-Antagonists / adverse effects,  pharmacology
Middle Aged
Parasympatholytics / adverse effects,  agonists
Piperazines / adverse effects,  pharmacology*
Prospective Studies
Pupil / drug effects*,  radiation effects
Quinoxalines / adverse effects,  pharmacology*
Quinuclidines / adverse effects,  pharmacology*
Triazoles / adverse effects,  pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Parasympatholytics; 0/Piperazines; 0/Quinoxalines; 0/Quinuclidines; 0/Triazoles; 59803-98-4/brimonidine; 72822-12-9/dapiprazole; 827-61-2/aceclidine
Comment In:
J Cataract Refract Surg. 2009 Oct;35(10):1845-6; author reply 1846   [PMID:  19781497 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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