Document Detail

Acebutolol-induced ventricular tachycardia reversed with sodium bicarbonate.
MedLine Citation:
PMID:  10465245     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acebutolol is a unique beta blocker that possesses cardioselectivity, partial agonist activity, and membrane stabilizing activity. Sodium bicarbonate is used to reverse the cardiotoxic effects of other drugs with membrane stabilizing activity. There have been no reported cases of acebutolol-induced ventricular dysrhythmias treated successfully with bolus sodium bicarbonate. CASE PRESENTATION: A 48-year-old man ingested approximately 6.4 g of acebutolol with ethanol (blood ethanol 61 mmol/L). There were no other coingestants identified. One hour after presentation, the patient had a cardiac arrest with the monitor showing ventricular tachycardia. Sodium bicarbonate 50 mEq intravenous push converted the patient to sinus rhythm and the blood pressure improved to 129/90 mm Hg. CONCLUSION: This case demonstrates a temporal relationship between bolus sodium bicarbonate administration and the termination of acebutolol-induced ventricular tachycardia.
K D Donovan; R V Gerace; J F Dreyer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  37     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  AIM; IM    
University of Western Ontario and London Health Sciences Centre.
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MeSH Terms
Acebutolol / poisoning*
Anti-Arrhythmia Agents / poisoning*
Drug Antagonism
Electrocardiography / drug effects
Middle Aged
Sodium Bicarbonate / administration & dosage,  therapeutic use*
Tachycardia / chemically induced*
Time Factors
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 144-55-8/Sodium Bicarbonate; 37517-30-9/Acebutolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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