Document Detail

Accurate prediction of fetal hemoglobin by Doppler ultrasonography.
MedLine Citation:
PMID:  12039117     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the feasibility of using the middle cerebral artery peak systolic velocity (MCA-PSV) to predict the actual value of fetal hemoglobin in fetuses undergoing a first cordocentesis for detection of anemia caused by maternal red cell alloimmunization. METHODS: Doppler velocimetry of the MCA-PSV was performed in 18 fetuses before an initial cordocentesis. Hemoglobin and MCA-PSV values were expressed as multiples of the median to adjust for the changes that both parameters demonstrate with gestational age. In each fetus we determined: 1) the expected (using a cubic mathematical function describing the correlation between fetal hemoglobin and MCA-PSV) and the observed (determined at the time of the cordocentesis) hemoglobin value; and 2) the percentage differences between the expected and the observed hemoglobin values. RESULTS: Gestational age at the time of the Doppler study ranged from 19 to 31 weeks. On 15 occasions, the fetuses demonstrated anemia. A quadratic relationship was found between the hemoglobin multiples of the median and the percentage differences between the expected and the observed hemoglobin values. As the values of hemoglobin decreased, the percentage difference between expected and observed values significantly decreased (R(2) = 0.48, P <.05). The cubic model estimated fetal hemoglobin well in severely anemic fetuses and less well when the fetus was not anemic. CONCLUSION: Doppler measurement of the MCA-PSV appears to be a valuable tool for estimating hemoglobin concentration in fetuses at risk for anemia. The correlation between hemoglobin and MCA-PSV becomes more accurate as the severity of anemia increases.
Giancarlo Mari; Laura Detti; Utku Oz; Roland Zimmerman; Peter Duerig; Theodor Stefos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  99     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-31     Completed Date:  2002-09-03     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-93     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Prenatal Diagnosis and Fetal Therapy Center, University of Virginia Health Science Center, Charlottesville, Virginia, USA.
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MeSH Terms
Anemia / ultrasonography*
Fetal Diseases / ultrasonography*
Fetal Hemoglobin / analysis*
Gestational Age
Middle Cerebral Artery / embryology*,  ultrasonography*
Ultrasonography, Doppler
Ultrasonography, Prenatal*
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

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