Document Detail

Accurate measurement of stable isotopes 46Ca and 48Ca in human feces, plasma, and urine in relation to human nutrition of calcium.
MedLine Citation:
PMID:  7261399     Owner:  NLM     Status:  MEDLINE    
A method based on Radiochemical Neutron Activation Analysis (RNAA) is described which allows simultaneous measurement of two stable isotopes of calcium, 46Ca and 48Ca, in human feces, plasma, and urine for the purpose of studying human nutrition and metabolism of calcium. It is shown that these measurements can be made with relative analytical precision of 1--5% depending on the particulars of a given experiment. The method has been applied in humans and data are given showing that kinetics of plasma appearance of 46 Ca administered orally with food can be readily investigated. This method allows investigation of a number of important nutritional and metabolic issues in all human population groups without regard to radioisotope safety considerations, and should prove especially helpful in relation to studies of calcium bioavailability from different foods in a variety of population groups for whom use of radiocalcium is not warranted.
M Janghorbani; A Sundaresan; V R Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  113     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-10-29     Completed Date:  1981-10-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  267-80     Citation Subset:  IM    
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MeSH Terms
Calcium / analysis*,  blood,  urine
Calcium Isotopes*
Calcium, Dietary / metabolism*
Feces / analysis
Neutron Activation Analysis / methods
Nutritional Physiological Phenomena*
Reg. No./Substance:
0/Calcium Isotopes; 0/Calcium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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