| Accurate fat fraction quantification by multiecho gradient-recalled-echo magnetic resonance at 1.5T in rats with nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21459536 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To assess the diagnostic accuracy of a new reconstruction technique for gradient-recalled-echo magnetic resonance (MR) sequences that provides a full decomposition of the water and fat content inside a voxel for nonalcoholic fatty liver disease (NAFLD) in rats. MATERIAL AND METHODS: Rats were randomized into two groups. A control group (n=10) was given free access to regular dry rat chow for 4 weeks. The steatosis (n=40) group was given free access to feed and water 4 days per week, and fasted for the remaining 3 days for 4 weeks. All rats were killed at 4 weeks and assessed for fatty infiltration and biochemical method. RESULTS: The average fat content using the gold standard method was 2.65g (2.20-3.05) of fat/100g liver for the control group and 4.14g (1.95-8.60) of fat/100g of liver for the overfed group (p<0.05). The average fat-fraction obtained from the MR was 0.016 (0.01-0.02) for the control group and 0.057 (0.00-0.18) for the overfed group. The Pearson correlation coefficient between the samples was r(2)=0.87. CONCLUSION: Multi-echo MR is a good technique to quantify liver fat in rats. |
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Authors:
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Elizabeth Hijona; Javier Sánchez-González; Jose M Alústiza; Lander Hijona; Juan Arenas; Elisabeth García; Nohelia Rojas; Maria P Portillo; Raúl Jiménez; Pablo Aldazabal; Luis Bujanda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Hospital Donostia, Department of Gastroenterology. Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD). University of Basque Country. Donostia-San Sebastián, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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