Document Detail


Accuracy of various subthalamic nucleus targeting methods and an appropriated formula for Thai patients.
MedLine Citation:
PMID:  20873076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has recently been the standard surgical treatment for Parkinson's disease. Besides appropriate selection of patients, precise STN targeting is the most crucial factor for good surgical outcomes. However, there is no single targeting method universally accepted as the most accurate technique. Thus, the authors studied the accuracy of various STN targeting methods and proposed a formula for Thai patients. MATERIAL AND METHOD: Sixteen patients with Parkinson's disease who fulfilled the intraoperative criteria of good STN targeting and had significant clinical improvements, without any stimulation-induced adverse effects, were included in the present study. Positions of the STN were determined by four targeting methods, direct targeting by axial T2W MRI, direct targeting by coronal T2W MRI, indirect targeting by anterior commissure-posterior commissure based formula and indirect targeting by adjustable digital Schaltenbrand-Wahren (SW) atlas, were compared with the final lead positions. The final lead positions by the four targeting methods were averaged to get an appropriate AC-PC based formula for Thai patients. RESULTS: The most accurate STN targeting method was axial T2W MRL followed by coronal T2W MRI, AC-PC based formula and the SW atlas, respectively. The averaged final lead positions obtained from the four methods was X = 11.5 +/- 1.0, Y = -3.3 +/- 1.0 and Z = -4.8 +/- 0.42 mm. CONCLUSION: The direct targeting by axial T2W MRI yielded the highest accuracy and the appropriate STN formula for Thai patients appeared to be X = +/- 11.5, Y = -3.5 (-3.3) and Z = -5.0 (-4.8) mm.
Authors:
Sarun Nunta-aree; Dilok Tuntongtip; Bunpot Sitthinamsuwan; Prajak Srirabheebhat; Akkapong Nitising; Teerapol Witthiwej
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  93     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-28     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1043-9     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sisna@mahidol.ac.th
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MeSH Terms
Descriptor/Qualifier:
Asian Continental Ancestry Group
Brain Mapping / methods
Deep Brain Stimulation / methods*
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging / methods
Male
Parkinson Disease / diagnosis,  physiopathology,  therapy*
Red Nucleus / pathology
Retrospective Studies
Stereotaxic Techniques / standards*
Subthalamic Nucleus / anatomy & histology,  physiopathology*
Thailand
Tomography, X-Ray Computed

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