Document Detail

Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt-Jakob disease.
MedLine Citation:
PMID:  8639066     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the sensitivity, specificity, and interobserver reliability of periodic sharp wave complexes in the electroencephalograms of patients with Creutzfeldt-Jakob disease. DESIGN: Sixty-eight electroencephalograms in 29 patients who had been suspected of having Creutzfeldt-Jakob disease were reanalyzed by an investigator who was unaware of the clinical data. The incidence of periodic sharp wave complexes in neuropathologically confirmed Creutzfeldt-Jakob disease vs progressive dementia other than Creutzfeldt-Jakob disease was assessed. Blinded electroencephalogram analysis was performed by a second investigator. The interobserver reliability was assessed by the kappa value. SETTING: University hospital, base of the German National Creutzfeldt-Jakob Disease Surveillance Study. PATIENTS: Fifteen patients with neuropathologically confirmed Creutzfeldt-Jakob disease and 14 patients who had been suspected of having Creutzfeldt-Jakob disease because of rapidly progressive dementia but in whom other dementias were diagnosed by unblinded investigators based on clinical and electroencephalographic criteria. MAIN OUTCOME MEASURE: Sensitivity and specificity of periodic sharp wave complexes assessed by their incidence in Creutzfeldt-Jakob disease vs other dementias. Interobserver reliability of periodic sharp wave complexes was expressed by the kappa value. RESULTS: For periodic sharp wave complexes, blinded electroencephalographic analysis resulted in a sensitivity and a specificity of 67% and 86%, respectively. Interobserver reliability was excellent (kappa = 0.95). CONCLUSION: This blinded electroencephalographic study in Creutzfeldt-Jakob disease confirms the high diagnostic value of electroencephalography, as previously reported by open studies.
B J Steinhoff; S Räcker; G Herrendorf; S Poser; S Grosche; I Zerr; H Kretzschmar; T Weber
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  53     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-05     Completed Date:  1996-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-6     Citation Subset:  AIM; IM    
Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany.
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MeSH Terms
Aged, 80 and over
Brain / physiopathology
Creutzfeldt-Jakob Syndrome / diagnosis*,  physiopathology
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity

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