Document Detail

Accuracy of real-time 3-dimensional echocardiography in the assessment of mitral prolapse. Is transesophageal echocardiography still mandatory?
MedLine Citation:
PMID:  18371478     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Segmental analysis in mitral prolapse is important to decide the chances of valvular repair. Multiplane transesophageal echocardiography (TEE) is the only echocardiographic tool validated for this aim hitherto. The aim of the study was to assess if segmental analysis can be performed with transthoracic real-time 3-dimensional (3D) echocardiography as accurately as with TEE, hence representing a valid alternative to TEE. METHODS: Forty-one consecutive patients diagnosed with mitral prolapse underwent TEE and a complete 3D echocardiography study, including parasternal and apical real-time; apical full-volume; and 3D color full-volume. Investigators performing TEE were blinded to the 3D results. RESULTS: Three-dimensional echocardiogram was feasible in 40 to 41 patients (97.7%). Ages ranged from 15 to 92 years, and all possible anatomical patterns of prolapse were represented. Thirty-seven patients (90.2%) had mitral regurgitation of any degree. The level of agreement was k = 0.93 (P < or = .0001), sensitivity of 96.7%, specificity of 96.7%, likelihood ratio for a positive result of 29.0%, and likelihood ratio for a negative result of 0.03%. Four false positives were found, corresponding to scallops A2 (1), A3 (2), and P3 (1). Four false negatives were found, corresponding to scallops A1 (2) and P1 (2). Sensitivity and specificity in the scallop P2 were 100%. CONCLUSION: Segmental analysis in mitral prolapse can be performed with transthoracic real-time 3D echocardiography as accurately as with TEE. False negatives tend to appear around the anterolateral commissure, whereas false positives tend to appear around the posteromedial commissure. Highest accuracy was reached in central scallops.
Juan Luis Gutiérrez-Chico; José Luis Zamorano Gómez; José Luis Rodrigo-López; Luis Mataix; Leopoldo Pérez de Isla; Carlos Almería-Valera; Adalia Aubele; Carlos Macaya-Miguel
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-02-21
Journal Detail:
Title:  American heart journal     Volume:  155     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-8     Citation Subset:  AIM; IM    
Department of Cardiovascular Imaging, Hospital Clínico San Carlos, Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Diagnostic Errors
Echocardiography, Three-Dimensional*
Echocardiography, Transesophageal*
Middle Aged
Mitral Valve / pathology,  ultrasonography*
Mitral Valve Prolapse / pathology,  ultrasonography*
Prospective Studies
Sensitivity and Specificity

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