Document Detail

Accuracy of prognostic and predictive markers in core needle breast biopsies compared with excisional specimens.
MedLine Citation:
PMID:  24944553     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Core needle biopsy (CNB) is widely accepted for preoperative diagnosis of breast cancer and sometimes can be the only way of providing a suitable specimen for prognostic and predictive marker studies prior to neoadjuvant treatment. The purpose of this study was to evaluate the accuracy of CNB by comparing histological tumor type and grade as well as estrogen receptor (ER), progesterone receptor (PR), p53, and HER2/ neu status by immunohistochemistry in CNB and excisional surgical specimens.
PATIENTS AND METHODS: During a 2.5-year study period, we identified 30 patients with breast cancer, who underwent CNB and definitive surgery. To evaluate the accuracy of CNB, tumor grade, ER, PR, HER2, and p53 status were immunohistochemically determined in both the CNB and the surgical specimens, and concordance of results between the 2 specimens was assessed.
RESULTS: The concordance rate was 100% for histological type, 66.6% for histological grade, and 96.7, 90, 76.7 and 93.3% for ER, PR, p53 and HER2/neu, respectively.
CONCLUSION: Our study showed that CNB has an excellent accuracy for tumor type, ER, and HER2/ neu; however, it should be used cautiously for tumor grade, PR, and p53 status. Thus, excisional biopsy is recommended for the determination of these factors.
Mohammad Motamedolshariati; Bahram Memar; Mohsen Aliakbaian; Mohammad T Shakeri; Mohammad Samadi; Ali Jangjoo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breast care (Basel, Switzerland)     Volume:  9     ISSN:  1661-3791     ISO Abbreviation:  Breast Care (Basel)     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-06-19     Completed Date:  2014-06-19     Revised Date:  2014-06-23    
Medline Journal Info:
Nlm Unique ID:  101254060     Medline TA:  Breast Care (Basel)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  -    
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